MedChem Highlights - Enamine

Enamine designs, develops and synthesizes chemical reagents, scaffolds and intermediates widely known as building blocks for their convenient use in medicinal chemistry and synthesis of combinatorial compound libraries. Our catalog has 1 375 309 diverse building blocks of various chemical classes that make it the largest and most abundant source of research chemicals in the world.

Fluorooxetanes

Anionic Amino Acids

Anionic Amino Acids

Spiropentanes

Highly Pyramidal Amides

Highly Pyramidal Amides

Cyclic Hydrazines

Cyclic Hydrazines

α-Fluoroamines

α-Fluoroamines

N-Methyl Amino Acids

N-Methyl Amino Acids

Sterically Hindered Amines

Sterically Hindered Amines

Photo Amino Acids

Photo Amino Acids

Cyclic 1,2-Diamine Scaffolds

Cyclic 1,2-Diamine Scaffolds

Fluoroprolines

Oxetane-incorporating Building Blocks

Oxetane-incorporating Building Blocks

α-Methyl Amino Acids

α-Methyl Amino Acids

Ladderanes

Diazole-based Peptide Bond Surrogates

Diazole-based Peptide Bond Surrogates

Thietane Dioxide

Thietane Dioxide

gamma-Amino Acids

Benzene Perfect Match

Benzene Perfect Match

Advances in Fluorinated Amino Acids

Advances in Fluorinated Amino Acids

3D-Shaped Scaffolds

3D-Shaped Scaffolds

Cationic Amino Acids

Cationic Amino Acids

Bicyclobutanes

P-, B- and Si-Containing Amino Acids

P-, B- and Si-Containing Amino Acids

SnAP Reagents

Heteroaromatic Amino Acids

Heteroaromatic Amino Acids

Trifluoromethylthio (SCF3) Compounds

Trifluoromethylthio (SCF₃) Compounds

Unnatural Amino Acids: Arylglycines

Unnatural Amino Acids: Arylglycines

Bifunctional Heterocyclic Scaffolds

Bifunctional Heterocyclic Scaffolds

Alkyl Sulfinates for Radical Cross-Coupling

Alkyl Sulfinates for Radical Cross-Coupling

Bridged Pyrrolidine with Reduced Lipophilicity

Bridged Pyrrolidine with Reduced Lipophilicity

Aliphatic Trifluoroborates

Aliphatic Trifluoroborates

Spirocyclic Piperidine Bioisostere

Spirocyclic Piperidine Bioisostere

Ideal Bioisostere for para-Substituted Benzene

Ideal Bioisostere for para-Substituted Benzene

Spirocyclic Benzene Bioisostere

Spirocyclic Benzene Bioisostere

N-Hydroxyphthalimide (NHPI) Esters for C-C Cross-coupling

N-Hydroxyphthalimide (NHPI) Esters for C-C Cross-coupling

7- and 8-Membered Rings for Medicinal Chemistry

7- and 8-Membered Rings for Medicinal Chemistry

Deuterium-Containing Building Blocks for Drug Design

Deuterium-containing Building Blocks

Saturated Bioisosteres for ortho-substituted Benzenes

Saturated Bioisosteres of ortho-Substituted Benzenes

N-Nitrosamines as Cancerogenic Impurities

N-Nitrosamines as Cancerogenic Impurities

Saturated bioisosteres of meta-substituted benzene

Fluorinated Benzodioxoles

Bioisosteres of tert-butyl group

Unique fluoroalkyl substituents

Aliphatic Sulfonyl Fluorides for SuFEx Click Chemistry

Spirocyclic Azetidines

Methyl Sulfoximines

CF3-Diazirines for photoaffinity labeling

CF₃-Diazirines for Photoaffinity Labeling

Boron-containing heterocyclic scaffolds with active halogens

Boron-containing Heterocyclic Scaffolds with Active Halogens

Aliphatic Pinacol Boronates for Medicinal Chemistry

Aliphatic Pinacol Boronates

Analogues of Piperidine for Drug Design

Analogues of Piperidine

Fluoroalkyl ethers for Drug Design

Fluoroalkyl Ethers

N-Trifluoromethyl Azoles for Drug Discovery

N-Trifluoromethyl Azoles

Cyclic sulfates and sulfamidates as alkylating reagents

Cyclic Sulfates and Sulfamidates as Alkylating Reagents

Functionalized Vinyl Boronates for C-C couplings

Functionalized Vinyl Boronates for C-C сouplings

Unique 3D-shaped Spirocycles to Explore Novel Chemical Space

Unique 3D-shaped Spirocycles

Water-soluble non-classical benzene mimics

Water-Soluble Non-classical Benzene Mimics

gem-Difluorinated Amines for Drug Design

gem-Difluorinated Amines

Fluorosulfates and Sulfamoyl Fluorides for Drug Design

Fluorosulfates and Sulfamoyl Fluorides

Alkyne-containing Linkers

Alkyne-containing Linkers

Structurally optimized tetrazines for rapid biological labeling

Structurally Optimized Tetrazines for Rapid Biological Labeling

Building blocks and linkers for PROTAC synthesis

Building Blocks and Linkers for PROTAC Synthesis

Heterocyclic Sulfonyl Fluorides for Pd-Catalyzed C‑C Coupling Reactions

Heterocyclic Sulfonyl Fluorides

Silicon-Containing Building Blocks

Silicon-сontaining Building Blocks

Epoxides for Drug Design

Analogues of CF3-Pyridine for Drug Design

Analogues of CF₃-Pyridine

Piperazine Bioisosteres for Drug Design

Piperazine Bioisosteres

Sugar-like Building Blocks for Drug Design

Sugar-like Building Blocks

Cyclic Sulfonamides for Drug Design

Cyclic Sulfonamides

Morpholine Bioisosteres for Drug Design

Morpholine Bioisosteres

P(O)Me2-containing Building Blocks for Drug Design

P(O)Me₂-containing Building Blocks

Saturated Bioisosteres of ortho-/meta-substituted Benzenes

Saturated Bioisosteres of ortho-/meta-substituted Benzenes

Saturated bioisosteres of para-substituted benzenes

Saturated Bioisosteres of para-substituted Benzenes

Sulfonyl Fluorides (-SO<sub>2</sub>F)

Sulfonyl fluorides (-SO₂F)

Diazirines - Photoreactive Building Blocks

Oxetane-containing Building Blocks

Oxetane-containing Building Blocks

SF<sub>5</sub>-Building Blocks

SF₅-Building Blocks

Stannanes for coupling reactions

Stannanes for Coupling Reactions

Sulfoximines for Drug Design

Heterocyclic scaffolds

Heterocyclic scaffolds

Azide-linkers for Drug Design

Unnatural Amino Acids

Unnatural Amino Acids

Cubanes for Medicinal Chemistry

Benzoxaboroles for Drug Design

Other classes of building blocks:

Fluorinated carboxylic acids

Sulfur pentafluorides

Azetidines

"Small" piperazines

Bicyclic amines

Pyrrolidines

Morpholines mimetics

Proline analogues

Diamine scaffolds

Non-classical benzene bioisosteres

Building Blocks by Functions

For Library Synthesis

DEL-compatible scaffolds