Modulating protein function through small-molecule binding is a key therapeutic strategy for numerous diseases. Molecular Glues are a class of small molecules that induce proximity between a target protein and an E3 ubiquitin ligase, resulting in selective degradation of the target protein. Recent advances in the discovery of Molecular Glues have greatly expanded the potential of targeted protein degradation, opening new avenues in drug discovery—particularly for proteins previously considered “undruggable.”
Leveraging global expertise in drug discovery and the powerful capabilities of Enamine’s REAL Space, we have assembled focused libraries of Molecular Glues designed to engage multiple E3 ligases.
Product catalog
DCAF-5440
Size
5 440
compounds
Descriptions
Designed to target DCAF family of E3 ligases
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IMiD Library
IMiD-4900
Size
4 900
compounds
Descriptions
Designed and specially synthesized for the discovery of Immunomodulatory Imide Drugs
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CRBN Molecular Glues Library
CRBN-MG-4560
Size
4 560
compounds
Description
Designed to capture the widest possible range of novel chemotypes of CRBN binders, providing a foundation for the discovery of next-generation Molecular Glues
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PAG Library
PAG-640
Size
640
compounds
Description
Built upon novel Phenyl Amino Glutarimide (PAG) analogs, these compounds combine structural innovation with potent activity — offering a fresh perspective in Molecular Glue design
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PD Library
PD-880
Size
880
compounds
Description
Chemical stability, cellular potency, and permeability are just a few of the advantages that make Phenyl Dihydrouracil (PD)-based CRBN ligands promising candidates for optimal Molecular Glue discovery
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PG Library
PG-800
Size
800
compounds
Description
Phenyl Glutarimide (PG)-based library was purposefully developed to expand the structural diversity space of Molecular Glues
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Len Library
Len-640
Size
640
compounds
Description
Lenalidomide- and Pomalidomide-scaffold based — a time-tested backbone, reimagined for modern Molecular Glue design
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AAG Library
AAG-1600
Size
1 600
compounds
Description
Acylated Amino Glutarimide (AAG) featuring 5- and 6-membered heterocyclic systems: a promising platform for the discovery of next-generation Molecular Glues
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Avadomide library
AVD-560
Size
560
compounds
Descriptions
A special selection of new Avadomide analogs
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Diverse CRBN Library
CRBN-960
Size
960
compounds
Descriptions
Designed to cover all structural diversity of CRBN binders, a key component of the E3 ubiquitin ligase complex
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CRBN Covalent Library
CCRBN-160
Size
160
compounds
Descriptions
A small selection of diverse covalent binders capable of interacting with CRBN
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VHL ligands and intermediates
VHL-80
Size
80
compounds
Descriptions
A versatile tool for discovering new VHL-based degraders
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Selected publications
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Molecular Glues Begin to Stick.
Vitale G. C&EN Global Enterp. 2022, 100 (29), 20– 24. DOI: 10.1021/cen-10029-cover -
Big Pharma eyes a slew of molecular glues.
Braner S. C&EN Global Enterp. 2024, 102 (36), 10. DOI: 10.1021/cen-10236-buscon2
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
