Designed to capture the widest possible range of novel chemotypes of CRBN binders, providing a foundation for the discovery of next-generation Molecular Glues
4 560 compounds
CRBN E3 ligase is a well-established and validated target for the development of Molecular Glues, as evidenced by the dozens of compounds currently undergoing various stages of clinical trials.
Leveraging the powerful capabilities of REAL Space, our CRBN Molecular Glues Library has been designed to cover a broad spectrum of CRBN binders. This includes the classical Lenalidomide scaffold, as well as alternative structures such as Phenyl Dihydrouracil (PD), Phenyl Amino Glutarimide (PAG), Phenyl Glutarimide (PG) scaffolds, and various Acylated Amino Glutarimide (AAG). Each of these scaffolds is represented by dedicated sublibraries, which can be ordered either as part of the comprehensive CRBN Molecular Glues Library or individually.
The library provides our clients with ready-to-use, optimized compounds, significantly accelerating the drug discovery process. Forget about lengthy synthesis from scratch—we provide access to a diverse array of molecules with distinct chemical properties, all prepared for immediate testing.
Сomposition of library by classes of CRBN binders
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Typical Formats
Catalog No.
CRBN-MG-4560-0-Z-20
Compounds
4 560
4 plates
Amount
≤ 300 nL of 20 mM of DMSO solutions
Plates and formats
1536-well Echo LDV microplates, first and last four columns empty, 1280 compounds per plate
Price
Catalog No.
CRBN-MG-4560-10-Y-20
Compounds
4 560
15 plates
Amount
10 µL of 20 mM DMSO solutions
Plates and formats
384-well Echo plates, Labcyte #LP-0200, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
CRBN-MG-4560-50-X-20
Compounds
4 560
57 plates
Amount
50 µL of 20 mM DMSO solutions
Plates and formats
96-well plates, 80 compounds per plate, first and last columns empty; Greiner #781270
Price
*We will be happy to provide our library in any other most convenient for your project format. Please select among the following our standard microplates: Greiner Bio-One 781270, 784201, 781280, 651201 or Echo Qualified 001-12782 (LP-0200), 001-14555 (PP-0200), 001-6969 (LP-0400), C52621 or send your preferred labware. Compounds pooling can be provided upon request.
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
