Establishing the lschemia-Reperfusion Model in Rats for Chronic Renal Pathology Investigations
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Sonidegib bioisosteres: activity and ADME properties
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An "Ideal" Bioisoster of the para-substituted Phenyl Ring
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Assessing the Efficacy of Various Kidney Injury Parameters in Predicting Acute Kidney Injury Outcomes
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Novel Class of Piperidine Bioisosteres
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The activity of Benzocaine benzene ring bioisosteres
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3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives
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3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives
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Chemical Landscape of Capping Agents for DNA-Encoded Technologies (DELT) from Enamine Perspective
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Diagonally protected 1-methylcyclobutane 1,3-diamines in Abrocitinib analogues synthesis
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Easy-to-perform large scale approach to 1-methyladamantane and its derivatives – scarce though prominent medchem building-blocks
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Efficient one-step approach to annulated tetrahydrofurans: supporting the search for new potent CCR2 receptor antagonists
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Thermal [2+2] synthesis of 3-oxocyclobutyl boronates via keteniminium salts
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Unexpected isomerization of azetidine-carboxylic acids
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Electrophilic [4+1]-cyclization of picolines – efficient avenue towards 6-azaindole and 6-azabenzofuranes
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gem-Difluoromethylene Decorated cyclic building blocks - impact on physicochemical properties
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Looking for an ideal HTS screening collection
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Novel chemotypes of angiotensin-converting enzyme 2 binders via successive in silico screening and in vitro evaluation approaches
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Polyfunctional Core Building Blocks for DNA-Encoded Technologies (DELT): the Definitive Factor for Libraries Diversity
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Synthesis of annulated azinopyrol heterocyclic frameworks as purine analogs
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Synthesis of versatile stellane derivatives in multigram scale
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Creation of alkyl substituent in α-position of methylene ketones: efficient synthetic toolbox
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Scale-up synthesis of 1-methyladamantane – key precursor to chiral methyl-phenyl-adamantane carboxamide with promising in vitro activity against Ebola virus
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Shelf-stable amino acid derived diazoketones – perspective reagents for medicinal chemistry
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Synthesis and properties of diverse pyrazolines based on flow-generated diazomethanes
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Trifluoromethyl vinamidinium salt – the promising precursor for fused pyridine-contained heterocycles
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2-Oxabicyclo[2.2.2]octane: A New Bioisostere of the Phenyl Ring
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Novel Class of Piperidine Bioisosteres
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Synthesis of 3-Azabicyclo[3.1.1]heptanes
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CF3-Diazirines for photoaffinity labeling
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Practical scalable synthesis of N-CF3 substituted heterocycles
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Unexpected isomerization of oxetane carboxylic acids
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Deoxofluorination of Aliphatic and (Hetero)aromatic Acids
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Convenient Access to Conformationally Rigid Sultams
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Cobalt-containing conducting polymers on carboneous supports for catalytic hydrogenation of quinoline
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Cu-Catalyzed Pyridine Annulation via Oxidative Reaction of Cyclic Ketones with Propargyl Amine
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Expanding of the scope of Castagnoli–Cushman reaction: Anhydrides of cyclic 1,2-dicarbonic acids
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Expanding of the scope of Castagnoli–Cushman Reaction: trifluoracetaldehyde monohydrate
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G3 and G4 Buchwald Precatalysts: Scale up, QC and application for the semi-automated parallel synthesis
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Isoxazole and 1,2,4-Oxadiazole-Derived Phosphonates via [3+2] Cycloaddition
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4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrazine: Lead-oriented scaffold with three diversity points
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Synthesis and reactivity of N-difluoro-cyclopropyl-substituted pyrazoles
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Quick evaluation of catalytic activity of hydrogenation cata-lysts by UV spectra using imidazo[1,5-a]pyridines as probes
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Recent Advances in Difluorocyclopropanation of alkenes using Ruppert–Prakash reagent
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Selective Methylation of α-Methylene Ketones
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Straightforward Synthesis of All Isomeric (Cyclo, fluoro)alkylpiperidines
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Synthesis and properties of monoalkylsubstituted difluorocyclopropenes
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Synthesis of gem-difluorocycloheptanes building blocks
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Difluoro-substituted bicyclo[1.1.1]pentanes (BCPs) for medicinal chemistry
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Novel spirocyclic and fused cyclopropane scaffolds for medicinal chemistry
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Piperazine Bioisosteres for Drug Design
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New Covalent Fragment Libraries by parallel synthesis
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P(O)Me2-containing Building Blocks for Drug Design
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Unexpected macrocycles formation in a synthesis of fused aza-cycloalkyl oxazoles
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One-step Synthesis of Functionalized Pyridines by Reaction of Propargylamine and Ketones Catalyzed by Cu(II) Compounds
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Evolution of commercially available compounds for HTS
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Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks
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Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks
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Catalytic Hydrogenation of Quinoline on Composites of Graphene-like Carbon and 3Dmetals or Their Oxides
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New frontiers in Castagnoli–Cushman Reaction
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An Efficient Approach To Novel Tetrahydropyridoazepines. Expansion Of Azepines’ Drug-like Chemical Space
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Synthesis of Gem-difluorocyclobutane/pentane/hexane Building Blocks – Useful Reagent For Drug Discovery
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Ruppert – Prakash reagent as a difluorocarbene synthetic equivalent for the synthesis of medchem-relevant building blocks
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Cyclobutane ring as a conformational restriction tool
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Saturated Bioisosteres of Benzene with Improved Solubility
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Cubanes for Drug Design
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CH-Activation of L-Proline analogues
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Application of AI to REAL Space: A Step Ahead to Expand the Synthetically Feasible Chemical Space
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Conformationally-rigid pyrrolidines with improved water solubility
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Aminosulfonyl fluorides for drug design
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Novel spirocycles for drug discovery
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Bicyclic amines for drug discovery by [2+2]-photocyclization
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1,3-Oxazoles and 1,2,4-oxadiazoles as selective agonists of GPR40 receptor
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Design and synthesis of novel 3D-shaped building blocks to “Escape the Flatland”
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Proline analogues: advanced building blocks for drug design
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New synthetic approach to diverse heterocyclic sulfonyl chlorides
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Conformationally restricted scaffolds by Double-Mannich reaction of cyclic ketones
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Synthesis of unique pyrrolidines for drug discovery
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Design and synthesis of morpholine analogues
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Novel fluorinated amines for drug discovery
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