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Establishing the lschemia-Reperfusion Model in Rats for Chronic Renal Pathology Investigations

Establishing the lschemia-Reperfusion Model in Rats for Chronic Renal Pathology Investigations

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Sonidegib bioisosteres: activity and ADME properties

Sonidegib bioisosteres: activity and ADME properties

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An 'Ideal' Bioisoster of the para-substituted Phenyl Ring

An "Ideal" Bioisoster of the para-substituted Phenyl Ring

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Assessing the Efficacy of Various Kidney Injury Parameters in Predicting Acute Kidney Injury Outcome

Assessing the Efficacy of Various Kidney Injury Parameters in Predicting Acute Kidney Injury Outcomes

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Novel Class of Piperidine Bioisosteres

Novel Class of Piperidine Bioisosteres

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The activity of Benzocaine benzene ring bioisosteres

The activity of Benzocaine benzene ring bioisosteres

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3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives

3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives

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3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives

3-CF3/C2F5 - Substituted Proline Analogs: Synthesis and Proteolytic Stability of Their Amide Derivatives

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Chemical Landscape of Capping Agents for DNA-Encoded Technologies (DELT) from Enamine Perspective

Chemical Landscape of Capping Agents for DNA-Encoded Technologies (DELT) from Enamine Perspective

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Diagonally protected 1-methylcyclobutane 1,3-diamines in Abrocitinib analogues synthesis

Diagonally protected 1-methylcyclobutane 1,3-diamines in Abrocitinib analogues synthesis

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Easy-to-perform large scale approach to 1-methyladamantane and its derivatives – scarce though prominent medchem building-blocks

Easy-to-perform large scale approach to 1-methyladamantane and its derivatives – scarce though prominent medchem building-blocks

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Efficient one-step approach to annulated tetrahydrofurans: supporting the search for new potent CCR2 receptor antagonists

Efficient one-step approach to annulated tetrahydrofurans: supporting the search for new potent CCR2 receptor antagonists

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Thermal [2+2] synthesis of 3-oxocyclobutyl boronates via keteniminium salts

Thermal [2+2] synthesis of 3-oxocyclobutyl boronates via keteniminium salts

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Unexpected isomerization of azetidine-carboxylic acids

Unexpected isomerization of azetidine-carboxylic acids

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Electrophilic [4+1]-cyclization of picolines – efficient avenue towards 6-azaindole and 6-azabenzofuranes

Electrophilic [4+1]-cyclization of picolines – efficient avenue towards 6-azaindole and 6-azabenzofuranes

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gem-Difluoromethylene Decorated cyclic building blocks - impact on physicochemical properties

gem-Difluoromethylene Decorated cyclic building blocks - impact on physicochemical properties

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Looking for an ideal HTS screening collection

Looking for an ideal HTS screening collection

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Novel chemotypes of angiotensin-converting enzyme 2 binders via successive in silico screening and in vitro evaluation approaches

Novel chemotypes of angiotensin-converting enzyme 2 binders via successive in silico screening and in vitro evaluation approaches

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Polyfunctional Core Building Blocks for DNA-Encoded Technologies (DELT): the Definitive Factor for Libraries Diversity

Polyfunctional Core Building Blocks for DNA-Encoded Technologies (DELT): the Definitive Factor for Libraries Diversity

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Synthesis of annulated azinopyrol heterocyclic frameworks as purine analogs

Synthesis of annulated azinopyrol heterocyclic frameworks as purine analogs

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Synthesis of versatile stellane derivatives in multigram scale

Synthesis of versatile stellane derivatives in multigram scale

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Creation of alkyl substituent in α-position of methylene ketones: efficient synthetic toolbox

Creation of alkyl substituent in α-position of methylene ketones: efficient synthetic toolbox

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Scale-up synthesis of 1-methyladamantane – key precursor to chiral methyl-phenyl-adamantane carboxamide with promising in vitro activity against Ebola virus

Scale-up synthesis of 1-methyladamantane – key precursor to chiral methyl-phenyl-adamantane carboxamide with promising in vitro activity against Ebola virus

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Shelf-stable amino acid derived diazoketones – perspective reagents for medicinal chemistry

Shelf-stable amino acid derived diazoketones – perspective reagents for medicinal chemistry

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Synthesis and properties of diverse pyrazolines based on flow-generated diazomethanes

Synthesis and properties of diverse pyrazolines based on flow-generated diazomethanes

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Trifluoromethyl vinamidinium salt – the promising precursor for fused pyridine-contained heterocycles

Trifluoromethyl vinamidinium salt – the promising precursor for fused pyridine-contained heterocycles

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2-Oxabicyclo[2.2.2]octane: A New Bioisostere of the Phenyl Ring

2-Oxabicyclo[2.2.2]octane: A New Bioisostere of the Phenyl Ring

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Novel Class of Piperidine Bioisosteres

Novel Class of Piperidine Bioisosteres

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Synthesis of 3-Azabicyclo[3.1.1]heptanes

Synthesis of 3-Azabicyclo[3.1.1]heptanes

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CF3-Diazirines for photoaffinity labeling

CF3-Diazirines for photoaffinity labeling

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Practical scalable synthesis of N-CF3 substituted heterocycles

Practical scalable synthesis of N-CF3 substituted heterocycles

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Unexpected isomerization of oxetane carboxylic acids

Unexpected isomerization of oxetane carboxylic acids

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Deoxofluorination of Aliphatic and (Hetero)aromatic Acids

Deoxofluorination of Aliphatic and (Hetero)aromatic Acids

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Convenient Access to Conformationally Rigid Sultams

Convenient Access to Conformationally Rigid Sultams

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Cobalt-containing conducting polymers on carboneous supports for catalytic hydrogenation of quinoline

Cobalt-containing conducting polymers on carboneous supports for catalytic hydrogenation of quinoline

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Cu-Catalyzed Pyridine Annulation via Oxidative Reaction of Cyclic Ketones with Propargyl Amine

Cu-Catalyzed Pyridine Annulation via Oxidative Reaction of Cyclic Ketones with Propargyl Amine

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Expanding of the scope of Castagnoli–Cushman reaction: Anhydrides of cyclic 1,2-dicarbonic acids

Expanding of the scope of Castagnoli–Cushman reaction: Anhydrides of cyclic 1,2-dicarbonic acids

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Expanding of the scope of Castagnoli–Cushman Reaction: trifluoracetaldehyde monohydrate

Expanding of the scope of Castagnoli–Cushman Reaction: trifluoracetaldehyde monohydrate

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G3 and G4 Buchwald Precatalysts: Scale up, QC and application for the semi-automated parallel synthesis

G3 and G4 Buchwald Precatalysts: Scale up, QC and application for the semi-automated parallel synthesis

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Isoxazole and 1,2,4-Oxadiazole-Derived Phosphonates via [3+2] Cycloaddition

Isoxazole and 1,2,4-Oxadiazole-Derived Phosphonates via [3+2] Cycloaddition

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4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrazine: Lead-oriented scaffold with three diversity points

4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrazine: Lead-oriented scaffold with three diversity points

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Synthesis and reactivity of N-difluoro-cyclopropyl-substituted pyrazoles

Synthesis and reactivity of N-difluoro-cyclopropyl-substituted pyrazoles

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Quick evaluation of catalytic activity of hydrogenation cata-lysts by UV spectra using imidazo[1,5-a]pyridines as probes

Quick evaluation of catalytic activity of hydrogenation cata-lysts by UV spectra using imidazo[1,5-a]pyridines as probes

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Recent Advances in Difluorocyclopropanation of alkenes using Ruppert–Prakash reagent

Recent Advances in Difluorocyclopropanation of alkenes using Ruppert–Prakash reagent

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Selective Methylation of α-Methylene Ketones

Selective Methylation of α-Methylene Ketones

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Straightforward Synthesis of All Isomeric (Cyclo, fluoro)alkylpiperidines

Straightforward Synthesis of All Isomeric (Cyclo, fluoro)alkylpiperidines

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Synthesis and properties of monoalkylsubstituted difluorocyclopropenes

Synthesis and properties of monoalkylsubstituted difluorocyclopropenes

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Synthesis of gem-difluorocycloheptanes building blocks

Synthesis of gem-difluorocycloheptanes building blocks

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Difluoro-substituted bicyclo[1.1.1]pentanes (BCPs) for medicinal chemistry

Difluoro-substituted bicyclo[1.1.1]pentanes (BCPs) for medicinal chemistry

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Novel spirocyclic and fused cyclopropane scaffolds for medicinal chemistry

Novel spirocyclic and fused cyclopropane scaffolds for medicinal chemistry

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Piperazine Bioisosteres for Drug Design

Piperazine Bioisosteres for Drug Design

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New Covalent Fragment Libraries by parallel synthesis

New Covalent Fragment Libraries by parallel synthesis

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P(O)Me2-containing Building Blocks for Drug Design

P(O)Me2-containing Building Blocks for Drug Design

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Unexpected macrocycles formation in a synthesis of fused aza-cycloalkyl oxazoles

Unexpected macrocycles formation in a synthesis of fused aza-cycloalkyl oxazoles

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One-step Synthesis of Functionalized Pyridines by Reaction of Propargylamine and Ketones Catalyzed by Cu(II) Compounds

One-step Synthesis of Functionalized Pyridines by Reaction of Propargylamine and Ketones Catalyzed by Cu(II) Compounds

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Evolution of commercially available compounds for HTS

Evolution of commercially available compounds for HTS

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Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

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Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

Synthesis of medchem-relevant Dimethylphosphine Oxide (DMPO) containing building blocks

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Catalytic Hydrogenation of Quinoline on Composites of Graphene-like Carbon and 3Dmetals or Their Oxides

Catalytic Hydrogenation of Quinoline on Composites of Graphene-like Carbon and 3Dmetals or Their Oxides

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New frontiers in Castagnoli–Cushman Reaction

New frontiers in Castagnoli–Cushman Reaction

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An Efficient Approach To Novel Tetrahydropyridoazepines. Expansion Of Azepines’ Drug-like Chemical Space

An Efficient Approach To Novel Tetrahydropyridoazepines. Expansion Of Azepines’ Drug-like Chemical Space

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Synthesis of Gem-difluorocyclobutane/pentane/hexane Building Blocks – Useful Reagent For Drug Discovery

Synthesis of Gem-difluorocyclobutane/pentane/hexane Building Blocks – Useful Reagent For Drug Discovery

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Ruppert – Prakash reagent as a difluorocarbene synthetic equivalent for the synthesis of medchem-relevant building blocks

Ruppert – Prakash reagent as a difluorocarbene synthetic equivalent for the synthesis of medchem-relevant building blocks

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Cyclobutane ring as a conformational restriction tool

Cyclobutane ring as a conformational restriction tool

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Saturated Bioisosteres of Benzene with Improved Solubility

Saturated Bioisosteres of Benzene with Improved Solubility

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Cubanes for Drug Design

Cubanes for Drug Design

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CH-Activation of L-Proline analogues

CH-Activation of L-Proline analogues

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Application of AI to REAL Space: A Step Ahead to Expand the Synthetically Feasible Chemical Space

Application of AI to REAL Space: A Step Ahead to Expand the Synthetically Feasible Chemical Space

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Conformationally-rigid pyrrolidines with improved water solubility

Conformationally-rigid pyrrolidines with improved water solubility

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Aminosulfonyl fluorides for drug design

Aminosulfonyl fluorides for drug design

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Difluorocyclopropanes for drug discovery

Difluorocyclopropanes for drug discovery

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Novel spirocycles for drug discovery

Novel spirocycles for drug discovery

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Bicyclic amines for drug discovery by [2+2]-photocyclization

Bicyclic amines for drug discovery by [2+2]-photocyclization

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1,3-Oxazoles and 1,2,4-oxadiazoles as selective agonists of GPR40 receptor

1,3-Oxazoles and 1,2,4-oxadiazoles as selective agonists of GPR40 receptor

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Design and synthesis of novel 3D-shaped building blocks to 'Escape the Flatland'

Design and synthesis of novel 3D-shaped building blocks to “Escape the Flatland”

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Proline analogues: advanced building blocks for drug design

Proline analogues: advanced building blocks for drug design

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New synthetic approach to diverse heterocyclic sulfonyl chlorides

New synthetic approach to diverse heterocyclic sulfonyl chlorides

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Conformationally restricted scaffolds by Double-Mannich reaction of cyclic ketones

Conformationally restricted scaffolds by Double-Mannich reaction of cyclic ketones

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Synthesis of unique pyrrolidines for drug discovery

Synthesis of unique pyrrolidines for drug discovery

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Design and synthesis of morpholine analogues

Design and synthesis of morpholine analogues

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Novel fluorinated amines for drug discovery

Novel fluorinated amines for drug discovery

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CF3CHN2 and C2F5CHN2: highly underestimated reagents

CF 3CHN 2and C 2F 5CHN 2: highly underestimated reagents

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