Real compounds

New chemical space for discovery

The chemical universe is immense. Have you ever thought that you can deal with virtual compounds as if they are from stock and benefit from low prices and assured quick delivery with minimum attrition? We can help you to escape from the availability bias and benefit from the huge diversity of drug-like compounds in your virtual screening campaigns and search for hit analogs. Having almost 240 000 building blocks in stock, we are ready at any moment to assemble the final molecules on your request in just 1-3 synthesis steps. We set no limitations on the number of compounds to synthesize and allow cherry-picking in the entire synthetically feasible space counting 21 billion REAL (REadily AccessibLe™) compounds.

We only need 3-4 weeks to ship you a library of ca. 100 compounds. For a typical order, the synthesis success rate normally attains 80% and higher. This is achieved because of the usage of only available in-stock building blocks. Moreover, each such reagent has been previously subjected to test reactions profiling its reactivity. Together with thorough validated chemical reactions and elaborated SOP’s these factors make the REAL compounds a unique product that allows for going beyond what is available in stock in the search for new hit compounds. Ordering the REAL compounds is the same as if you order compounds from stock.

There are two principal solutions to access REadily AccessibLe™ compounds. The REAL Database lists enumerated REAL compounds. You can download it or search online. The REAL Space is also accessed via InfiniSee, a software tool generating REAL compounds that are similar by pharmacophore(s) to your query structure. This tool does not use the database and searches in a fragment space.

Facts about the REAL:
  1. Criteria of the REAL compounds: typical amount ordered, ≤ 10 mg; synthesis time, 3-4 weeks for a set of 100-200 molecules (includes a single experiment, workup, purification, and formatting steps); purity, > 90% (accessed by LC-MS).
  2. There are two types of the REAL compounds: “s_” and “m_” compounds assembled via standard or advanced synthetic procedures, respectively. The “m_” REAL compounds also include molecules that require special purification and compound management conditions. The average synthesis success rate is 80% for the “s_” REAL compounds, and 65% for the “m_” REAL compounds.
  3. The success rate of >80% is achieved for the random selections of over 100 REAL compounds synthesized within 4 weeks in a 1-5 mg amount. The success rate is typically higher when the synthesis period is prolonged. The success rate and synthesis time may vary for focused selections (i.e. selections of mostly the “m” REAL compounds, selections based on the same building block, selections which include the same type of the compounds, etc.).

REAL compounds

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