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Modern drug discovery requires contemporary compound libraries. We synthesize 300,000 new compounds annually and select the best candidates for our compound libraries. We offer over 100 fast-to-deliver pre-plated compound libraries for various research needs, from large-scale HTS screens to assay-specific and proteomics studies.

  • Positive screening outcome. We conduct in-depth analysis of the research field and collaborate with leading industry experts to design our libraries.
  • Premium quality. We produce compound libraries using only over 90%-pure compounds with analytics (LCMS and/or NMR) not older than one year. We filter compounds that are unstable in DMSO, have poor solubility, and undesirable salts. We also track the number of freeze-thaw cycles to determine pre-plated libraries shelf life based on their nature (cf. covalent vs non-covalent and other sensitive classes). When resupplying the hits, we follow our defined procedure, tracking the compound batches and their analytics. We purify or even resynthesize samples free of charge if they are of poor quality.
  • Resupply from dry powders. For the library preparation, we use compounds available at 10+ mg in our stock so that they can be resupplied from the same batch. We have a program in place to maintain the dry sample stock levels through resynthesis for compounds present in REAL Space. For the best and fastest results, we encourage integrated lead discovery projects involving our biological screening, computational chemistry, efficient Hit-to-Lead using our REAL Space, ADMET/PK, and MedChem support.

Diversity Libraries

A complete suite of non-overlapping screening libraries ranging from 5k to 500k compounds. Diverse and carefully selected from lead-like chemotypes to provide new hits even for well-known targets.

Targeted Libraries

Libraries of choice when the target or its character are known: kinases, RNA’s, GPCR’s, PPI’s, CNS, etc. An increased number of hits can be found even with smaller libraries.

Fragment Libraries

A wide repertoire of Fragment Libraries designed in collaboration with renowned experts in various fields of FBDD. Each fragment is reviewed and tested to comply with high quality and synthetic tractability requirements.

Covalent Libraries

Sets of binders for the screening of known and developing of (yet) undruggable targets. Select between the sets focused on warheads (acrylamides, chloroacetamides, boronics), residue (Cys-, Ser-, Lys-) and targets (M-Pro).

Bioactive Libraries

Our selection of compound libraries with known biological activity ranging from published HTS hits to FDA-approved drugs.

Catalog

We offer over 60 ready-to-deliver pre-plated compound libraries in a variety of custom formats. Our well-equipped liquid handling department will make a library copy in any convenient for you project format.

 

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