Modern drug discovery requires contemporary compound libraries. We synthesize 300,000 new compounds annually and select the best candidates for our compound libraries. We offer over 100 fast-to-deliver pre-plated compound libraries for various research needs, from large-scale HTS screens to assay-specific and proteomics studies.
- Positive screening outcome. We conduct in-depth analysis of the research field and collaborate with leading industry experts to design our libraries.
- Premium quality. We produce compound libraries using only over 90%-pure compounds with analytics (LCMS and/or NMR) not older than one year. We filter compounds that are unstable in DMSO, have poor solubility, and undesirable salts. We also track the number of freeze-thaw cycles to determine pre-plated libraries shelf life based on their nature (cf. covalent vs non-covalent and other sensitive classes). When resupplying the hits, we follow our defined procedure, tracking the compound batches and their analytics. We purify or even resynthesize samples free of charge if they are of poor quality.
- Resupply from dry powders. For the library preparation, we use compounds available at 10+ mg in our stock so that they can be resupplied from the same batch. We have a program in place to maintain the dry sample stock levels through resynthesis for compounds present in REAL Space. For the best and fastest results, we encourage integrated lead discovery projects involving our biological screening, computational chemistry, efficient Hit-to-Lead using our REAL Space, ADMET/PK, and MedChem support.
