Libraries Catalog

Description

Diverse covalent library with most demanded warhead types

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Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

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Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

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Diverse covalent warheads with balanced reactivity

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Library of Cys-specific covalent electrophilic binders

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Special selection of Serine focused irreversible binders

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The ultimate selection of Lys-specific binders

Description

Characterized by a new HTS thiol-reactivity assay

Descriptions

Diverse screening Acrylamides pre-plated at 10 mM concentration

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Representative selection of fragment Acrylamides pre-plated at 100 mM stock concentration

Descriptions

Library of diverse HTS-size chloroacetamides pre-plated at 10 mM concentration

Descriptions

Diverse strict Ro3 compliant chloroacetamides plated at 100 mM stock concentartion

Descriptions

Representative selection of N-, O-linked and Aryl sulfonyl fluorides within fragment space

Description

Enantiomeric pairs of covalent electrophilic fragments

Description

Covalent Heterocyclic Fragment Library for identification of Cryptic and Allosteric Pocket

Descriptions

Designed to target DCAF family of E3 ligases

Descriptions

Designed and specially synthesized for the discovery of Immunomodulatory Imide Drugs

Description

Designed to capture the widest possible range of novel chemotypes of CRBN binders, providing a foundation for the discovery of next-generation Molecular Glues

Description

Built upon novel Phenyl Amino Glutarimide (PAG) analogs, these compounds combine structural innovation with potent activity — offering a fresh perspective in Molecular Glue design

Description

Chemical stability, cellular potency, and permeability are just a few of the advantages that make Phenyl Dihydrouracil (PD)-based CRBN ligands promising candidates for optimal Molecular Glue discovery

Description

Phenyl Glutarimide (PG)-based library was purposefully developed to expand the structural diversity space of Molecular Glues

Description

Lenalidomide- and Pomalidomide-scaffold based — a time-tested backbone, reimagined for modern Molecular Glue design

Description

Acylated Amino Glutarimide (AAG) featuring 5- and 6-membered heterocyclic systems: a promising platform for the discovery of next-generation Molecular Glues

Descriptions

A special selection of new Avadomide analogs

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Designed to cover all structural diversity of CRBN binders, a key component of the E3 ubiquitin ligase complex

Descriptions

A small selection of diverse covalent binders capable of interacting with CRBN

Descriptions

A versatile tool for discovering new VHL-based degraders

Description

Focused on targeting the top CRLs that have been explored as the most promising targets

Description

Designed to target 3 HECT E3 Ligases for the discovery of new-generation drugs

Description

Designed for discovery of RNF216, RNF19A, PRKN, RNF13 potent binders and modulators

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Designed for modulation of the largest DUBs family and delivery of a promising treatment for incurable diseases

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Designed to deliver new and efficient modulators of CCR5, HTR2A, HTR2B, MRGPRX1, CXCR6, CMKLR2, CCR10, GPR3, GPR4, GPR39, CCR4 receptors

Description

Designed to deliver reliable hits for over 10 essential targets involved in the Hippo pathway

Description

Designed for hit finding for Hsp90, Hsp70, Hsp60, HspD1, ClpP, Ch60 and Hsp100 protein targets

Description

A new approach for modulating the most investigated and effective drug targets with good clinical records

Description

Designed to target the most investigated and validated for drug discovery PARPs

Description

The hottest protein targets for discovering new treatments for the most challenging and not yet treated diseases

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Library of compounds intended for use in agro/crop science

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Designed for discovery of novel allosteric ligands

Description

Carefully selected molecules via docking and visual evaluation

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Designed for the discovery of novel antibacterials

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Designed for the discovery of new effective and safe treatment

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Designed for discovery of new Nucleoside-like antivirals

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Designed for discovery of new water channels modifiers

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Designed for discovery of novel BACE inhibitors

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Specially selected molecules to target bromodomains

Description

Designed for discovery of new Voltage-gated calcium channel blockers

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Library of novel small molecules with high CNS MPO scores

Description

Sublibrary of CNS-47 Library

Description

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

Description

Designed for identification of new actives against proteins essential for DNA stability

Description

Library of compounds focusing to hit on a number of epigenetic targets

Description

Designed to effectively target the receptor and block estrogen release

Description

Specially synthesized set of compounds able to mimic glycosides and their interaction with proteins

Description

Designed for discovery of new GPCR ligands

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Designed for discovery of novel kinase ATP pocket binders

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IDO focused library designed by a combination of structure- and ligand-based methods

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Designed for discovery of novel hits in Immuno-Oncology therapeutic area

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Designed for discovery of new Ion Channels ligands

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Designed for efficient hit finding against a number of immune disorders, including RA

Description

Designed for discovery of novel protein kinase inhibitors

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Designed for discovery of new regulators of methabolic disorders

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A sub-library of Enamine’s GPCR Library designed for discovery of novel lipid GPCR ligands

Description

A set of LOXs inhibitors designed using docking and 2D similarity search

Description

A set of compounds focused on targeting molecular chaperones

Descriptions

Small library of specially synthesized compounds

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Sublibrary of PPI-40

Descriptions

Selected molecules able to mimic common protein motifs

Descriptions

Designed for discovery of novel PPI inhibitors

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Designed to promote the discovery of new-generation medicines

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Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

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Designed for discovery of new Nav^1.7 channel blockers

Description

Library of potential tubulins ligands

Description

Designed for the discovery of new effective modulators of Wnt/β-catenin signaling pathway

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Elaborated tool for initial screen

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Fragments of high MedChem tractability

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Designed for easy and rapid follow-up synthesis

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Guiding optimisation of fragment-derived lead compounds

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Diverse covalent warheads with balanced reactivity

Description

Specially designed for ¹⁹F NMR ligand-based screening

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Designed for easy and efficient exploration of novel protein targets

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Source of biologically validated starting points

Description

Unique 3D diversity among shaped molecules

Description

Fragments able to mimic protein structural motifs and hot-spot residues

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Fragments for easy-to-analyse protein-ligand interaction

Description

Designed for specific protein targets and sensible onset

Description

The most medchem reliable source of carboxylic acids replacement

Description

Library of high diversity of halogen bonding motifs

Description

Characterized by a new HTS thiol-reactivity assay

Description

Covalent Heterocyclic Fragment Library for identification of Cryptic and Allosteric Pocket

Description

CNS-friendly molecules capable of BBB penetration

Description

Enantiomeric pairs of covalent electrophilic fragments

Description

Size-optimized fragment library efficiently covering pharmacophore space, developed using ChemPass's Universal Fragment Library (UFL) Design Platform.

Description

General fragment library developed with ChemPass's Universal Fragment Library (UFL) Design Platform.

Description

Represents the diversity of structures and molecular targets of all FDA-approved chemical entities (Nat Chem Biol 13 (2017), 771–778)

Description

Actives with extensive target classes’ coverage and the broadest possible therapeutic areas applications – from CNS agents and anti-infectives to anticancer drugs, steroids and molecular glues.

Description

Most relevant selection of drugs in one formulation/no duplicates. Contains WHO List of Essential Medicines including Lapatinib and latest approved drugs such as Tivozanib, etc.

Description

Compounds with referred biological activity for repurposing or investigation of new pathways and mechanisms

Description

Library of cell penetrated compounds and their closest analogs. Covers diverse therapeutic areas from antitumor, neurology and antibacterial to aging diseases.

Description

Frequent hitters with most diverse scaffold selection – from small hydroquinone and other covalent modifiers to polyfluorinated highly lipophilic molecules and dyes.

Description

Curated selection of frequent hitters