Lipid GPCR Library

A sub-library of Enamine’s GPCR Library designed for discovery of novel lipid GPCR ligands

5 440 compounds

Enamine’s Lipid GPCR Library has been designed in collaboration with NQuiX. Over 5 440 compounds have been selected from off-the-shelf collection or specifically synthesized for this project from Enamine REAL screening Collection. They were designed to target the family of eight endothelial differentiation gene (EDG) receptors (S1P1–5 and LPA1–3). The compounds may also be appropriate for screening at GPR3, GPR6 and GPR12 orphan receptors given some TM bundle binding site similarity and/or GPR23, GPR92 and P2Y5 given their more recent classification as additional, albeit distinct, LPA receptors.

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

LGR-5-Y-0

Compounds

5 440
157 plates

Amount

Any suitable for 1 assay

Plates and formats

384-well microplates, first two and last two columns empty, 320 compounds per plate

Price

This email address is being protected from spambots. You need JavaScript enabled to view it.

Catalog No.

LGR-5-Z-5

Compounds

5 440
40 plates

Amount

5 µL of 10 mM DMSO stock solutions

Plates and formats

1536-well microplates, Echo Qualified, first four and last four columns empty, 1280 compounds per plate

Price

This email address is being protected from spambots. You need JavaScript enabled to view it.

Catalog No.

LGR-5-Y-50

Compounds

5 440
157 plates

Amount

50 µL of 10 mM DMSO solutions

Plates and formats

384-well microplates, first two and last two columns empty, 320 compounds per plate

Price

This email address is being protected from spambots. You need JavaScript enabled to view it.

Catalog No.

LGR-5

Compounds

5 440

Amount

Custom

Plates and formats

Any custom format

Price

This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Get more details

Download SD files

Lipid GPCR Library

Library code: LGR-5

Version: 6 June 2020

5 440 compounds

sublibrary of GPR-54

Library design

The compounds have been selected using a combination of ligand-based methods using chemical fingerprints, 2D pharmacophores and 3D shape/feature matches (Figure 1). The training active compound set included 1 393 compounds (870 acidic and 523 non-acidic), collected across 73 papers (Figure 2). They represent a combination of compounds for expanding SAR around known chemotypes and scaffold hops seeking novelty. The current set of compounds covers the non-acidic classes of ligand, with acidic compounds being designed via a different procedure and added to the library separately.

 

Fig. 1.Dedicated design of the compounds included in the Library (general scheme).

Fig. 2. Distribution of the compounds in the training set.

Examples of the molecules

GPCR Library

FOLLOW US

Contact us

I have read and agree with Privacy Policy of Enamine

Send me details