Covalent Libraries

Since 2016 Enamine synthesize over 15 000 new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.

Product catalog

Product name
Size
Description
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Size

11 760
compounds

Description

Diverse covalent library with most demanded warhead types

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&nsbp;

Size

12 160
compounds

Description

Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

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&nsbp;

Size

2 640
compounds

Description

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

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&nsbp;

Size

8 480
compounds

Description

Diverse covalent warheads with balanced reactivity

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&nsbp;

Size

3 200
compounds

Description

Library of Cys-specific covalent electrophilic binders

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&nsbp;

Size

1 600
compounds

Description

Special selection of Serine focused irreversible binders

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&nsbp;

Size

1 600
compounds

Description

The ultimate selection of Lys-specific binders

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&nsbp;

Size

960
compounds

Description

Characterized by a new HTS thiol-reactivity assay

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&nsbp;

Covalent MiniFrags

CMF‑141

Size

141
compounds

Description

Covalent Heterocyclic Fragment Library for identification of Cryptic and Allosteric Pocket

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&nsbp;

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Support

  • Hit Confirmation: QC check, HPLC repurification, resynthesis
  • Hit follow-up: analogs search from stock or REAL Database
  • Fast hit exploration libraries synthesis

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

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