Covalent Libraries
Since 2016 Enamine synthesize over 15 000 new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.
Product catalog
CSL-11760
Size
11 760
compounds
Description
Diverse covalent library with most demanded warhead types
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Covalent Serine Hydrolase Library
CSHL-12160
Size
12 160
compounds
Description
Designed for discovery of mild electrophilic inhibitors of the largest enzyme class
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Coronavirus Mpro covalent Library
MPC-2640
Size
2 640
compounds
Description
Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals
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CFL-7360
Size
7 360
compounds
Description
Diverse covalent warheads with balanced reactivity
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Cysteine focused covalent fragments
CYS-3200
Size
3 200
compounds
Description
Library of Cys-specific covalent electrophilic binders
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Serine focused covalent fragments
SER-1600
Size
1 600
compounds
Description
Special selection of Serine focused irreversible binders
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Lysine focused covalent fragments
LYS-1600
Size
1 600
compounds
Description
A unique set of 1 600 Lys specific binders
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Electrophilic Covalent Probe Library
ECPL-960
Size
960
compounds
Description
Characterized by a new HTS thiol-reactivity assay
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Support
- Hit Confirmation: QC check, HPLC repurification, resynthesis
- Hit follow-up: analogs search from stock or REAL Database
- Fast hit exploration libraries synthesis
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.