Since 2016 Enamine synthesize over 15 000 new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.
Product catalog
CSL-11760
Size
11 760
compounds
Description
Diverse covalent library with most demanded warhead types
Download file
Covalent Serine Hydrolase Library
CSHL-12160
Size
12 160
compounds
Description
Designed for discovery of mild electrophilic inhibitors of the largest enzyme class
Download file
Coronavirus Mpro covalent Library
MPC-2640
Size
2 640
compounds
Description
Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals
Download file
CFL-8480
Size
8 480
compounds
Description
Diverse covalent warheads with balanced reactivity
Download file
Cysteine-Focused Covalent Library
CYS-3200
Size
3 200
compounds
Description
Library of Cys-specific covalent electrophilic binders
Download file
Serine-Focused Covalent Library
SER-1600
Size
1 600
compounds
Description
Special selection of Serine focused irreversible binders
Download file
Lysine-Focused Covalent Library
LYS-1600
Size
1 600
compounds
Description
The ultimate selection of Lys-specific binders
Download file
Electrophilic Covalent Probe Library
ECPL-960
Size
960
compounds
Description
Characterized by a new HTS thiol-reactivity assay
Download file
sACR-4080
Size
4 080
compounds
Descriptions
Diverse screening Acrylamides pre-plated at 10 mM concentration
Download file
fACR-2240
Size
2 240
compounds
Descriptions
Representative selection of fragment Acrylamides pre-plated at 100 mM stock concentration
Download file
sCLA-1200
Size
1 200
compounds
Descriptions
Library of diverse HTS-size chloroacetamides pre-plated at 10 mM concentration
Download file
Chloroacetamide Fragment Library
fCLA-1360
Size
1 360
compounds
Descriptions
Diverse strict Ro3 compliant chloroacetamides plated at 100 mM stock concentartion
Download file
SFF-640
Size
1 120
compounds
Descriptions
Representative selection of N-, O-linked and Aryl sulfonyl fluorides within fragment space
Download file
Size
960
compounds
Description
Enantiomeric pairs of covalent electrophilic fragments
Download file
CMF‑141
Size
141
compounds
Description
Covalent Heterocyclic Fragment Library for identification of Cryptic and Allosteric Pocket
Download file
Support
- Hit Confirmation: QC check, HPLC repurification, resynthesis
- Hit follow-up: analogs search from stock or REAL Database
- Fast hit exploration libraries synthesis
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.