Covalent Libraries
Since 2016 Enamine synthesize 15 000+ new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.
CSL-11200
Size
11 200 compounds
Description
Diverse Covalent Library with most demanded warhead types
Download file
Covalent Serine Hydrolase Library
CSHL-12160
Size
12 160 compounds
Description
Designed for discovery of mild electrophilic inhibitors of the largest enzyme class
Download file
Coronavirus Mpro covalent Library
MPC-2640
Size
2 640 compounds
Description
Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals
Download file
CFL-7360
Size
7 360 fragments
Description
Diverse covalent warheads with balanced reactivity
Download file
Cysteine focused covalent fragments
CYS-3200
Size
3 200 fragments
Description
Library of Cys-specific covalent electrophilic binders
Download file
Serine focused covalent fragments
SER-1600
Size
1 600 fragments
Description
Special selection of Serine focused irreversible binders
Download file
Lysine focused covalent fragments
LYS-1600
Size
1 600 fragments
Description
A unique set of 1 600 Lys specific binders
Download file
Electrophilic Covalent Probe Library
ECPL-960
Size
960 fragments
Description
Characterized by a new HTS thiol-reactivity assay
Download file
Support
- Hit Confirmation: QC check, HPLC repurification, resynthesis
- Hit follow-up: analogs search from stock or REAL Database
- Fast hit exploration libraries synthesis
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.