Covalent Libraries

Since 2016 Enamine synthesize 15 000+ new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.

Product name
Format/Size
Descriptions
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Format/Size

11 200 compounds

Descriptions

Diverse Covalent Library with most demanded warhead types

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&nsbp;

Format/Size

12 160 compounds

Descriptions

Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

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&nsbp;

Format/Size

2 640 compounds

Descriptions

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

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&nsbp;

Format/Size

7 360 fragments

Descriptions

Diverse covalent warheads with balanced reactivity

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&nsbp;

Format/Size

3 200 fragments

Descriptions

Library of Cys-specific covalent electrophilic binders

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&nsbp;

Format/Size

1 600 fragments

Descriptions

Special selection of Serine focused irreversible binders

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&nsbp;

Format/Size

1 600 fragments

Descriptions

A unique set of 1 600 Lys specific binders

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&nsbp;

Format/Size

960 fragments

Descriptions

Characterized by a new HTS thiol-reactivity assay

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&nsbp;

Support

  • Hit Confirmation: QC check, HPLC repurification, resynthesis
  • Hit follow-up: analogs search from stock or REAL Database
  • Fast hit exploration libraries synthesis

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

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