Covalent Libraries

Since 2016 Enamine synthesize 15 000+ new covalent compounds each year. This greatly contributes to the constant updating of our libraries in line with the latest trends in covalent warheads.

Library
Size
Description
SD file

Library

Covalent Screening Library
CSL-11200

Size

11 200 compounds

Descriptiont

Diverse Covalent Library with most demanded warhead types

SD file

&nsbp;

Library

Serine Hydrolase Library
SHL-12560

Size

12 560 compounds

Descriptiont

Designed for discovery of mild electrophilic inhibitors of the largest enzyme class

SD file

&nsbp;

Size

2 640 compounds

Descriptiont

Designed for the discovery of new SARS-CoV-2 and pan-Coronavirus antivirals

SD file

&nsbp;

Library

Covalent Fragment Library
CFL-7360

Size

7 360 fragments

Descriptiont

Diverse covalent warheads with balanced reactivity

SD file

&nsbp;

Size

3 200 fragments

Descriptiont

Library of Cys-specific covalent electrophilic binders

SD file

&nsbp;

Size

1 600 fragments

Descriptiont

Special selection of Serine focused irreversible binders

SD file

&nsbp;

Size

1 600 fragments

Descriptiont

A unique set of 1 600 Lys specific binders

SD file

&nsbp;

Size

960 fragments

Descriptiont

Characterized by a new HTS thiol-reactivity assay

SD file

&nsbp;

Support

  • Hit Confirmation: QC check, HPLC repurification, resynthesis
  • Hit follow-up: analogs search from stock or REAL Database
  • Fast hit exploration libraries synthesis

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

FOLLOW US

Contact us

I have read and agree with Privacy Policy of Enamine

Send me details