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Diverse covalent warheads with balanced reactivity

8 480 compounds

Covalent chemical probes have become essential for drug discovery in recent years. The impressive number of successful applications in protein drugability assessment, proteomics, and investigation of protein functions brought aspiration to the discovery of new covalent modifiers.

We are continuously working on elaborating parallel chemistry approaches and the synthesis of new covalent compounds of various classes. Enamine Covalent Collection comprises over 133k covalent binders and is frequently updated with new warhead types. The acquired experience and knowledge on stability and selectivity were applied to the design of our new Covalent Fragment Library.

The renewed library has been designed to represent Enamine’s most recent scaffolds in combination with the most interesting covalent anchors. Careful choice of the latest attractive and highly tractable covalent functionalities makes this library the most reliable source of covalent fragments.

All compounds passed rigorous QC before formatting to ensure the high quality of our library.

Covalent Fragment Library is available for fast supply in multiple formats, including the following most popular options.

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

Covalent Fragment Library
CFL-8480-40-Y-20

Compounds

8 480
27 plates

Amount

40 μL of 20 mM DMSO solutions

Plates and formats

384-well plates, Labcyte PP-0200; 320 compounds per plate; 1, 2 and 23,24 columns empty

Price

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Catalog No.

Covalent Fragment Library
CFL-8480

Compounds

8 480

Amount

Custom

Plates and formats

Any custom format

Price

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Catalog No.

Acrylamide Library
ACR-2240-20-Y-100

Compounds

2 240
7 plates

Amount

20 μL of 100 mM DMSO solutions

Plates and formats

384-well microplates, Greiner #781280; 320 compounds per plate; first two and last two columns empty

Price

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Catalog No.

Cyanacrylamide Library
CACR-800-25-X-100

Compounds

800
10 plates

Amount

25 μL of 100 mM DMSO solutions

Plates and formats

96-well plates, Greiner #650201; 80 compounds per plate; 1 and 12 columns empty

Price

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Catalog No.

Chloroacetamide Library
CLA-1360-50-X-100

Compounds

1 360
17 plates

Amount

50 μL of 100 mM DMSO solutions

Plates and formats

96-well plates, 2D-barcoded Matrix #4271; 80 compounds per plate; 1 and 12 columns empty

Price

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Catalog No.

Butynamide Library
BTA-400-100-X-20

Compounds

400
5 plates

Amount

100 μL of 20 mM DMSO solutions

Plates and formats

96-well plates, Greiner #650201; 80 compounds per plate; 1 and 12 columns empty

Price

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Catalog No.

Bicyclobutanes Library
BCB-320-40-Y-20

Compounds

320
1 plates

Amount

40 μL of 20 mM DMSO solutions

Plates and formats

384-well echo plates, Labcyte PP-0200; 320 compounds per plate; 1, 2 and 23, 24 columns empty

Price

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Download SD files

Covalent Fragment Library

Library code: CFL-8480

Version: 22 November 2023

8 480 compounds

Acrylamide Fragments

Library code: ACR-2240

Version: 10 May 2023

2 240 compounds

Chloroacetamide Fragments

Library code: CLA-1360

Version: 22 November 2023

1 360 compounds

Cyanacrylamide Fragments

Library code: CACR-800

Version: 3 July 2023

800 compounds

Butynamide Fragments

Library code: BTA-400

Version: 10 May 2023

400 compounds

Bicyclobutanes Library

Library code: BCB-320-40-X-20

Version: 9 August 2023

320 compounds

Sulfonyl Fluorides

Version: 30 July 2023

960 compounds

Disulfide Fragments

Library code: DSF-320

Version: 10 July 2023

320 compounds

Key features

  • Careful choice of warheads: only experimentally confirmed reactivity, no over-reactive warheads, no alternative reactive functionalities.
  • Stable in DMSO and suitable for multiple freeze-thaw cycles.
  • Advanced covalent binders: balanced reactivity covalent binders, no promiscuous binders
  • Fragments are pre-plated by classes and can be acquired separately.
  • The latest compounds featuring renowned Enamine Building Blocks.

Composition of the Library by the type of covalent binders

Composition of the Library by the type of covalent binders

Examples of compounds in the library

Examples of compounds in the library
 

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