Covalent Fragment Library

Diverse covalent warheads with balanced reactivity

7 360 compounds

Covalent chemical probes have become a hot topic in drug discovery within last few years. The impressive number of successful applications in protein drugability assessment and in investigation of enzymes functions brought aspiration to discovery of new covalent modifiers. However, further progress in this area is limited by availability of new covalent fragments with balanced molecular properties. We have elaborated parallel chemistry approaches to the synthesis of new libraries encompassing covalent fragments of various classes. Only within last two years Enamine has synthesized 32 000+ new covalent binders using automated parallel chemistry. The acquired knowledge on stability and selectivity was applied to design of our new Covalent Fragment Library.

Renewed library has been designed to represent Enamine’s most recent scaffolds in combination with most interesting covalent anchors. Careful choice of the latest attractive and highly tractable covalent functionalities makes this library the most reliable source of covalent fragments.

All compounds passed QC check before formatting to ensure quality of our library.

Covalent Fragment Library has been pre-plated for most convenient and fast supply in multiple formats, including the following most popular options:


Catalog No.
Compounds
Amount
Format
Price

Catalog No.

Covalent Fragment Library
CFL-7360-40-Y-20

Compounds

7 360
23 plates

Amount

40 μL of 20 mM DMSO solutions

Formats

384-well plates, Labcyte PP-0200;
320 compounds per plate;
1, 2 and 23,24 columns empty

Price

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Catalog No.

Acrylamide Library
ACR-2240-20-Y-100

Compounds

2 240
7 plates

Amount

20 μL of 100 mM DMSO solutions

Formats

384-well microplates, Greiner #781280;
320 compounds per plate;
first two and last two columns empty

Price

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Catalog No.

Cyanacrylamide Library
CACR-480-25-X-100

Compounds

480
6 plates

Amount

25 μL of 100 mM DMSO solutions

Formats

96-well plates, Greiner #650201;
80 compounds per plate;
1 and 12 columns empty

Price

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Catalog No.

Chloroacetamide Library
CLA-1360-50-X-100

Compounds

1 360
17 plates

Amount

50 μL of 100 mM DMSO solutions

Formats

96-well plates, 2D-barcoded Matrix #4271;
80 compounds per plate;
1 and 12 columns empty

Price

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Catalog No.

Butynamide Library
BTA-400-100-X-20

Compounds

400
5 plates

Amount

100 μL of 20 mM DMSO solutions

Formats

96-well plates, Greiner #650201;
80 compounds per plate;
1 and 12 columns empty

Price

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Catalog No.

Aziridine & Epoxide Library
EPOAZD-640-40-Y-20

Compounds

640
2 plates

Amount

40 μL of 20 mM DMSO solutions

Formats

384-well echo plates, Labcyte PP-0200;
320 compounds per plate;
1, 2 and 23,24 columns empty

Price

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Please request for any other format or compounds pooling. We will be happy to deliver our libraries in any convenient for your project formats.

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Key features

  • Careful choice of warheads: only experimentally confirmed reactivity, no over-reactive warheads, no alternative reactive functionalities.
  • Stable in DMSO and suitable for multiple freeze-thaw cycles.
  • Advanced covalent binders: reactivity-controlled covalent binders, N/O-sulfonyl fluorides, azididines, expoxides, 2‑chloropropionamides.
  • Fragments pre-plated by classes and can be acquired separately.
  • The latest compounds featuring renowned Enamine Building Blocks.

Composition of the Library by the type of covalent binders

Examples of compounds in the library

Examples of compounds in the library

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