Covalent Fragment Library

Diverse covalent warheads with balanced reactivity

6 120 compounds

Covalent chemical probes have become a hot topic in drug discovery within last few years. The impressive number of successful applications in protein drugability assessment and in investigation of enzymes functions brought aspiration to discovery of new covalent modifiers. However, further progress in this area is limited by availability of new covalent fragments with balanced molecular properties. We have recently elaborated parallel chemistry approaches to synthesis of new libraries encompassing covalent fragments of various classes. Only within last year Enamine has synthesized over 18,000 new covalent binders by parallel chemistry. The acquired knowledge on stability and selectivity was applied to design of our new Covalent Fragment Library.

Key features

  • Careful choice of warheads: only experimentally confirmed reactivity, reported in the literature!
  • The latest achievements in covalent anchor chemistry, new modification of well-known covalent moieties.
  • Advanced covalent warheads: reactivity-controlled covalent binders, N/O-sulfonyl fluorides, azididines, expoxides, 2-chloropropionamides.
  • Fragments plated by classes and can be acquired separately.
  • Novel compounds featuring renowned Enamine Building Blocks.

Renewed library has been designed to represent Enamine’s most recent scaffolds in combination with well-validated covalent warheads. Careful choice of highly tractable and attractive covalent functionalities makes this library the most reliable source of covalent fragments. All compounds passed QC check (90%+ purity) before formatting to ensure quality of our library.

Distribution by covalent warheads

Covalent Fragment Library available in pre-plated format and can be quickly supplied in multiple formats including the following popular options:


Catalog ID
Compounds
Amount
Formats*
Price

Catalog ID

Covalent Fragment Library
CFL-6120-5-Z-100

Compounds

6 120

Amount

5 μL of 100 mM
DMSO solutions

Formats

1536-well microplates, Labcyte acoustic LDV,
1 280 compounds per plate

Catalog ID

Acrylamide Sub-library
ACR-2240-25-Y-100

Compounds

2 240

Amount

25 μL of 100 mM
DMSO solutions

Formats

384-well plates, Greiner microplates, Cat. No. 781280, first two and last two columns empty

Catalog ID

Chloroacetamide Sub-library
CLA-1920-50-X-20

Compounds

1 920

Amount

50 μL of 20 mM
DMSO solutions

Formats

96-well plates, Greiner Cat. No. 650201
80 cmpds per plate; 1 and 12 columns empty

*Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

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Examples of compounds in the library

Examples of compounds in the library

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