120 000 Fragment compounds
including 10 000 covalent binders
Fragments
NEWS
June 25, 2019
June 25, 2019
Enamine’s covalent fragments
produce potent and unique hits
In a recent JACS paper several academic groups collaborated on discovery of novel covalent inhibitors using a library of 993 acrylamides and chloroacetamides sourced from Enamine’s covalent fragment collection. The design was focusing on mild electrophiles that were supposed to overcome the selectivity challenge. The library was characterized by a new high-throughput thiol-reactivity assay and screened against 10 cysteine-containing proteins. Potent and unique primary hits have been found in the majority (7 out of 10) of cases.
A refined library used in the research with a few frequent hitters and excessively reactive fragments removed is available from Enamine on request >
Ref.: J. Am. Chem. Soc. 2019, 141, 8951−8968
Reach out to new chemical space breaking the availability bias:
11 000 000 000 molecules and beyond
REAL compounds
NEWS
June 24, 2019
June 24, 2019
Atomwise and Enamine to Advance Pediatric Oncology With the World’s First and Largest Ten Billion Compound Virtual Screen
10 Billion REAL compounds will be searched using AI powered drug screening platform to find novel small molecules for the treatment of pediatric cancers. In collaboration with academic researchers, Atomwise and Enamine said the “10-to-the-10 program” will seek to maximize the opportunity to develop drugs for new target proteins to inhibit cancer growth and metastasis. Read PRESS RELEASE >
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