Saturated 3D scaffolds are widely used in pharmaceutical design. Their small size and high sp3 character aid in evading metabolic clearance, improving drug pharmacokinetics. Among these, bicyclo[1.1.1]pentane has proven particularly effective as a substituent and in isosteric replacements. However, its isomer, bicyclo[2.1.0]pentane (housane), has remained largely unexplored. Recently, interest in this motif has been growing, though only in patents. Be among the first to incorporate this unique structure in your work—explore our collection of bicyclo[2.1.0]pentane building blocks.
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More than 25 bicyclo[2.1.0]pentanes from stock on a 5-10 g scale.
