Fragment Libraries

Enamine Fragment Collection currently contains 200 000+ fragments being the largest and most reliable source of quality fragments. A number of focused fragment libraries were designed to perfectly meet needs of our clients. We collaborate with the leading experts in FBDD field on design and supply of top fragment libraries.

Library
Size
Description
SD file

Size

320 compounds

Descriptiont

Elaborated tool for initial screen

SD file

&nsbp;

Size

1 920 compounds

Descriptiont

Fragments of high MedChem tractability

SD file

&nsbp;

Library

DSI-poised Library
DSI-860

Size

860 compounds

Descriptiont

Designed for easy and rapid follow-up synthesis

SD file

&nsbp;

Size

80 compounds

Descriptiont

Guiding optimisation of fragment-derived lead compounds

SD file

&nsbp;

Library

Covalent Fragment Library
CFL-7360

Size

7 360 fragments

Descriptiont

Diverse covalent warheads with balanced reactivity

SD file

&nsbp;

Size

1 000 compounds

Descriptiont

Specially designed for 19F NMR ligand-based screening

SD file

&nsbp;

Size

640 fragments

Descriptiont

Designed for easy and efficient exploration of novel protein targets

SD file

&nsbp;

Size

4 160 compounds

Descriptiont

Source of biologically validated starting points

SD file

&nsbp;

Size

1 200 compounds

Descriptiont

Unique 3D diversity among shaped molecules

SD file

&nsbp;

Library

PPI Fragment Library
PPIF-3600

Size

3 600 compounds

Descriptiont

Fragments able to mimic protein structural motifs and hot-spot residues

SD file

&nsbp;

Size

1 500 compounds

Descriptiont

Fragments for easy-to-analyse protein-ligand interaction

SD file

&nsbp;

Size

4 000 compounds

Descriptiont

Designed for specific protein targets and sensible onset

SD file

&nsbp;

Library

Halogen-enriched Fragment Library

Size

3 000 compounds

Descriptiont

Library of high diversity of halogen bonding motifs

SD file

Size

960 fragments

Descriptiont

Characterized by a new HTS thiol-reactivity assay

SD file

&nsbp;

Support

  • Hit Confirmation: QC check, HPLC repurification, resynthesis
  • Hit follow-up: analogs search from stock or REAL Database
  • Fast hit exploration libraries synthesis

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

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