Fragment Libraries

Enamine Fragment Collection currently contains 220k fragments being the largest and most reliable source of quality fragments. A number of focused fragment libraries were designed to perfectly meet needs of our clients. We collaborate with the leading experts in FBDD field on design and supply of top fragment libraries.

Product name
Size
Description
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Size

320
compounds

Description

Elaborated tool for initial screen

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&nsbp;

Size

1 920
compounds

Description

Fragments of high MedChem tractability

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&nsbp;

Size

860
compounds

Description

Designed for easy and rapid follow-up synthesis

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&nsbp;

Size

80
compounds

Description

Guiding optimisation of fragment-derived lead compounds

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&nsbp;

Size

8 480
compounds

Description

Diverse covalent warheads with balanced reactivity

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&nsbp;

Size

1 000
compounds

Description

Specially designed for 19F NMR ligand-based screening

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&nsbp;

Size

640
compounds

Description

Designed for easy and efficient exploration of novel protein targets

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&nsbp;

Size

4 160
compounds

Description

Source of biologically validated starting points

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&nsbp;

Size

1 200
compounds

Description

Unique 3D diversity among shaped molecules

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&nsbp;

Size

3 600
compounds

Description

Fragments able to mimic protein structural motifs and hot-spot residues

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&nsbp;

Size

1 500
compounds

Description

Fragments for easy-to-analyse protein-ligand interaction

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&nsbp;

Size

4 000
compounds

Description

Designed for specific protein targets and sensible onset

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&nsbp;

Halogen-enriched Fragment Library

Size

3 000
compounds

Description

Library of high diversity of halogen bonding motifs

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Size

960
compounds

Description

Characterized by a new HTS thiol-reactivity assay

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&nsbp;

Size

142
compounds

Description

Covalent MiniFrags for identification of Cryptic and Allosteric Pocket

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&nsbp;

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Support

  • Hit Confirmation: QC check, HPLC repurification, resynthesis
  • Hit follow-up: analogs search from stock or REAL Database
  • Fast hit exploration libraries synthesis

We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.

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