Fragment Libraries
Enamine Fragment Collection currently contains 200 000+ fragments being the largest and most reliable source of quality fragments. A number of focused fragment libraries were designed to perfectly meet needs of our clients. We collaborate with the leading experts in FBDD field on design and supply of top fragment libraries.
Library
Essential Fragment LibraryESS-320
Size
320 compounds
Descriptiont
Elaborated tool for initial screen
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Library
High Fidelity Fragment LibraryHFF-1920
Size
1 920 compounds
Descriptiont
Fragments of high MedChem tractability
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Library
DSI-poised Library LibraryDSI-860
Size
860 compounds
Descriptiont
Designed for easy and rapid follow-up synthesis
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Library
Size
80 compounds
Descriptiont
Guiding optimisation of fragment-derived lead compounds
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Library
Covalent Fragment LibraryCFL-6120
Size
6 120 compounds
Descriptiont
Diverse covalent warheads with balanced reactivity
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Library
Fluorinated Fragment LibraryFDS-1000
Size
1 000 compounds
Descriptiont
Specially designed for 19F NMR ligand-based screening
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Library
Size
640 fragments
Descriptiont
Designed for easy and efficient exploration of novel protein targets
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Library
Natural Product-like FragmentsNPL-4160
Size
4 160 compounds
Descriptiont
Source of biologically validated starting points
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Library
Size
1 200 compounds
Descriptiont
Unique 3D diversity among shaped molecules
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Library
PPI Fragment LibraryPPIF-3600
Size
3 600 compounds
Descriptiont
Fragments able to mimic protein structural motifs and hot-spot residues
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Library
Single Pharmacophore Fragments SFP-1500
Size
1 500 compounds
Descriptiont
Fragments for easy-to-analyse protein-ligand interaction
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Library
Carboxylic Acid Fragment LibraryCAF-4000
Size
4 000 compounds
Descriptiont
Designed for specific protein targets and sensible onset
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Library
Halogen-enriched Fragment Library
Size
3 000 compounds
Descriptiont
Library of high diversity of halogen bonding motifs
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Library
Size
960 fragments
Descriptiont
Characterized by a new HTS thiol-reactivity assay
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Support
- Hit Confirmation: QC check, HPLC repurification, resynthesis
- Hit follow-up: analogs search from stock or REAL Database
- Fast hit exploration libraries synthesis
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.