Fragment Libraries
Enamine Fragment Collection currently contains 200 000+ fragments being the largest and most reliable source of quality fragments. A number of focused fragment libraries were designed to perfectly meet needs of our clients. We collaborate with the leading experts in FBDD field on design and supply of top fragment libraries.
ESS-320
Format/Size
320 compounds
Descriptions
Elaborated tool for initial screen
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High Fidelity Fragment Library
HFF-1920
Format/Size
1 920 compounds
Descriptions
Fragments of high MedChem tractability
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DSI-860
Format/Size
860 compounds
Descriptions
Designed for easy and rapid follow-up synthesis
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Format/Size
80 compounds
Descriptions
Guiding optimisation of fragment-derived lead compounds
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CFL-7360
Format/Size
7 360 fragments
Descriptions
Diverse covalent warheads with balanced reactivity
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FDS-1000
Format/Size
1 000 compounds
Descriptions
Specially designed for 19F NMR ligand-based screening
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Format/Size
640 fragments
Descriptions
Designed for easy and efficient exploration of novel protein targets
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Natural Product-like Fragments
NPL-4160
Format/Size
4 160 compounds
Descriptions
Source of biologically validated starting points
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3D Shape Diverse Fragment Library
3DF-1200
Format/Size
1 200 compounds
Descriptions
Unique 3D diversity among shaped molecules
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PPIF-3600
Format/Size
3 600 compounds
Descriptions
Fragments able to mimic protein structural motifs and hot-spot residues
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Single Pharmacophore Fragments
SPF-1500
Format/Size
1 500 compounds
Descriptions
Fragments for easy-to-analyse protein-ligand interaction
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Carboxylic Acid Fragment Library
CAF-4000
Format/Size
4 000 compounds
Descriptions
Designed for specific protein targets and sensible onset
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Halogen-enriched Fragment Library
Format/Size
3 000 compounds
Descriptions
Library of high diversity of halogen bonding motifs
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Electrophilic Covalent Probe Library
ECPL-960
Format/Size
960 fragments
Descriptions
Characterized by a new HTS thiol-reactivity assay
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Support
- Hit Confirmation: QC check, HPLC repurification, resynthesis
- Hit follow-up: analogs search from stock or REAL Database
- Fast hit exploration libraries synthesis
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.