Fragments for easy-to-analyse protein-ligand interaction
1 500 compounds
Recently, it was proposed that fragments with a single pharmacophore (i. e. polar group or other moiety for binding to a protein) have advantages over those with multiple, distally separated functional groups. This design approach is believed to maximize the advantages of FBDD, first of all through increasing synthetic capabilities of the fragment growth at the hit follow-up step. Applying these guidelines, we have created a library of single pharmacophore fragments.
Typical Formats
Catalog No.
SPF-1500-10-Y-100
Compounds
1 5005 plates
Amount
10 µL of 100 mM DMSO stock solutions
Plates and formats
384-well microplates, Echo qualified Labcyte, 320 compounds per plate
Price
Catalog No.
SPF-1500-25-Y-100
Compounds
1 5005 plates
Amount
25 µL of 100 mM DMSO stock solutions
Plates and formats
384-well microplates, Echo qualified Labcyte, 320 compounds per plate
Price
Catalog No.
SPF-1500-50-Y-100
Compounds
1 5005 plates
Amount
50 µL of 100 mM DMSO stock solutions
Plates and formats
384-well microplates, Echo qualified Labcyte, 320 compounds per plate
Price
Catalog No.
SPF-1500
Compounds
1 500
Amount
Custom
Plates and formats
Any custom format
Price
Download SD file
Key features:
- All the compounds pass both strict “ Ro2-like” physicochemical and most stringent in-house structural filters excluding PAINS, highly reactive and toxic motifs.
- High variety of both pharmacophores and scaffolds bearing them
- Rapid follow-up/fragment growth using both readily available in-stock and synthetic analogs from Enamine Fragments, Screening Collection and REAL Database
Examples of the molecules in the library
Molecular properties
