Fragment Collection

The World largest and continuously enhanced source of in-stock fragments

206 034 compounds

Fragment screening has become a mainstream technology in small molecules Drug Discovery programs and not only. Chemical Biology, which is extremely rapidly evolving now, needs reliable tools to navigate research. Fragments have also proved their efficacy in the discovery of new chemical probes, which reveal fundamental biological insights.

Committed to expanding chemical space Enamine has synthesized over 284 000 building blocks and developed REAL Compounds, both to contribute to the success of its abundant Fragment Collection. Not only reflect our fragments contemporary trends in FBDD, such as fragments bearing covalent warheads and photolabels, but also can they be easily grown into leads. All fragments can be easily followed with analogues from stock or through express synthesis.


We collaborate with the leading experts in FBDD to design and synthesize libraries for the most challenging projects filling gaps in the accessible chemical space. We continuously improve the quality of our fragments by providing more assurance on their solubility and stability. We keep screening our new fragments to assure stability of DMSO solutions and comply with solubility of at least 100 mM in DMSO and 1 mM in aqueous buffer.

Key features

  • Novelty and high chemotype diversity
  • Replenished, significant amount in stock, typically 100 mg+ and purity 95%
  • Design of custom libraries – target focused, assay-dedicated or chemotype based
  • Close analogs in stock and quick follow-up library synthesis
  • Hit confirmation and follow-up support

Currently, we offer 14 different pre-plated fragment libraries. We extensively work on improvement of all fragment libraries to bring the best starting points to your Fragment screening campaign.

Our presence in global FBDD

  1. Moonshot COVID-19 project: Fragment to lead
  2. Enamine to be the exclusive supplier of Astex’ MiniFrag Library. Read press release >>>
  3. Enamine Supplies DSI Poised Fragment and Analogue Libraries to Diamond Light Source1 XChem Facility and SGC Oxford. Read press release >>>
  4. Fragment libraries designed to be functionally diverse recover protein binding information more efficiently than standard structurally diverse libraries
    Carbery A., Skyner R., von Delft F., Deane CM. Cold Spring Harbor Laboratory 2022. DOI: 10.1101/2022.03.18.484642
  5. Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
    Resnick E., Bradley A., Gan J. et al. J. Am. Chem. Soc. 2019, 141, 22, 8951–8968. DOI: 10.1021/jacs.9b02822
  6. Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds
    Jose A., Guest D., LeGay R. et al. ChemMedChem. 2022, 17(7), e202100641. DOI: 10.1002/cmdc.202100641
  7. An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor
    Zaidman D., Gehrtz P., Filep M. et al. Cell Chem Biol. 2021, 28(12), 1795-1806. DOI: 10.1016/j.chembiol.2021.05.018
  8. (Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library
    Tolmachova K., Moroz Y., Konovets A. et al. ACS Comb. Sci. 2018, 20, 11, 672–680. DOI: 10.1021/acscombsci.8b00130
  9. NMR quality control of fragment libraries for screening
    Sreeramulu S., Richter C., Kuehn T. et al. J Biomol NMR. 2020, 74(10-11), 555-563. DOI: 10.1007/s10858-020-00327-9
  10. Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
    Douangamath A., Fearon D., Gehrtz P. et al. Nat Commun. 2020, 11(1), 5047. DOI: 10.1038/s41467-020-18709-w


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