News & Press Releases

Proteros biostructures and Orion Pharma agree on a long-term multi-target collaboration including the assembly of a joint novel and unique HTS small-molecule screening library with the full chemistry support of Enamine  

• Multi-target research partnership for drug discovery in oncology and pain
• Assembly of novel high-diversity small molecule library
• Library collection distinguished by novel unique design concepts based on a proprietary set of selection filters to ensure high quality and drug-likeness of individual compounds, selectively compiled from the premium chemical provider Enamine and others

Martinsried/Munich, Germany – September 06, 2023 – Proteros biostructures GmbH (“Proteros”) today announced a new collaboration with Orion Corporation (Espoo, Finland). The companies are engaging in a joint multi-target collaboration for early-stage drug discovery projects using Proteros’ “High Hanging Fruit” Discovery Platform, and now have decided to combine their expertise to assemble a unique and chemically diverse small molecule library collection. The non-exclusive agreement enables Proteros to exclusively offer access to this high-quality non-redundant HTS library to all their clients.

Under the agreement, Orion co-funded and supported the design and generation of the library containing a highly diverse collection of chemotypes for target-agnostic high throughput screening (HTS). The small molecule collection, of around 200 thousand compounds, is distinguished by its novel and unique design concept of optimized chemical diversity. Compounds are sourced primarily from the premium chemical provider Enamine a current partner of Proteros for hit follow-up chemistry services. Application of a comprehensive proprietary set of selection filters secures high quality and drug-likeness of the human-inspected individual compounds and reduces pan-assay interference compounds (PAINS) to guarantee that every compound is developable and follows desirable chemical properties. The established long-lasting collaboration with Enamine ensures high tractability and fast development of the hit compounds.

“With this novel library, we aim to enable the exploration of a highly diverse chemical space for our customers. The chemotype selection is based on stringent diversity algorithms and is ensured to be applicable to any target class,” said Lars Neumann, Director Discovery Solutions of Proteros biostructures. “This unique design allows us to offer our clients an excellent option for discovering Qualified Hits for High Hanging Fruit targets,” said Debora Konz Makino Vice President Discovery Solutions of Proteros biostructures.

“Based on our long-term experience and success of working with Proteros we are confident this agreement will boost our hit finding activities. One of the key features of

the library is also quick SAR by catalogue which will speed up hit triage significantly and allows best choice for lead optimisation programs. As we all know, quality of the hits is a key success factor for speed and success in the drug discovery program,” said Leena Otsomaa, Vice President Medicine Design of Orion Corp. “We are also very much looking forward to the collaboration for early-stage drug discovery in our key therapeutic target areas: oncology and pain indications.”

Michael Bossert, Head Strategic Alliances at Enamine, commented: “Our growing homemade screening libraries, the largest collection available in the world, constitute ideal starting points for any HTS and hit identification platform to spot possible beneficial effects against any of a large number of diseases.” He continued: “We are delighted to have been selected for this initiative as the main compound provider, and, under such collaboration, to enhance the partnership with Proteros to serve their clients each time when needed via our seamless hit follow-up chemistry services and our ADMET/DMPK capabilities.”

About Proteros biostructures GmbH

Proteros is a privately-held company with expertise in structure-based drug discovery powered by a cutting-edge discovery engine tailored to unlock even the most technically challenging disease-relevant drug targets. The company provides small molecule drug discovery services and its comprehensive enabling technology platforms, coupled with roots to Nobel Prize winning science and the Max Planck Institute of Biochemistry, have enabled prominent contributions to several lead optimization programs and clinical-stage compounds.

Proteros’ scientific rigor can accelerate overall research timelines for clients by solving the “High-hanging-fruits” of the early drug discovery and development stages and the company is consistently seen as the go-to partner for Hit to Lead Optimisation services. Proteros supports many of the world’s top 20 largest pharmaceutical companies and more than 200 pharmaceutical and biotech partners in the U.S., Europe and Japan.

For more information, please visit www.proteros.com.

About Orion Corp.

Orion is a globally operating Finnish pharmaceutical company – a builder of well-being. We develop, manufacture and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. We believe that health and well-being create the foundation for a good life and society. Orion has an extensive portfolio of proprietary and generic medicines and self-care products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion are used to treat cancer, neurological and respiratory diseases, among others. Orion's net sales in 2022 amounted to EUR 1,341 million and the company had about 3,500 employees at the end of the year. Orion's A and B shares are listed on Nasdaq Helsinki.

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Namiki and Enamine have collaborated for over 20 years, and for the most part of this time, Namiki was an exclusive distributor of all Enamine products and services. Namiki is an excellent partner providing services on the highest level under any circumstances.

Barcelona, Spain, and Kyiv, Ukraine, April 27, 2023. Nostrum Biodiscovery, a leading provider of computational drug discovery services, and ENAMINE, a global supplier of chemical building blocks and screening compounds, announced today a groundbreaking collaboration for the co-development of a revolutionary search engine tailored for the REAL Space billion database. This partnership aims to deliver unparalleled performance in searching vast chemical spaces while utilizing low computational resources, thus increasing the efficiency and accessibility of drug discovery efforts.

The collaboration will also focus on enhancing High Throughput Virtual Screening (HTVS) services to streamline the drug discovery process. Nostrum Biodiscovery's state-of-the-art AI-enabled screening platform will take center stage in this effort, boasting the capability to evaluate the entire billion compound collection in just hours. This innovative technology promises to identify potential drug candidates within weeks, significantly accelerating the discovery pipeline.

ENAMINE’s expertise in the rapid and reliable provision of compounds will further strengthen the collaboration, ensuring that researchers have timely access to the vast array of molecules in the REAL Space database. This partnership will facilitate the seamless integration of Nostrum Biodiscovery's computational prowess with ENAMINE’s extensive compound collection, directly impacting companies interested in using services offered by both partners and ultimately benefiting the global scientific community and accelerating the path to new drug discoveries.

[Victor Guallar, CSO Nostrum Biodiscovery] “We see it every day in our projects, using the REAL Space database with our AI/MM hybrid HTVS platform is a game changer in finding molecules. Our joint venture with ENAMINE demonstrates our commitment to integrating cutting-edge technology and high-quality compound collections to provide the pharmaceutical industry with unparalleled access to resources that expedite drug discovery. We believe that this partnership will serve as a catalyst for innovation, inspiring ventures to explore uncharted territories in the quest for novel therapeutics.”

[Andrey Tarnovskiy, Sales Director, Europe at Enamine] “This year the size of Enamine’s REAL Space has reached tremendous 36 Billion compounds. We are excited to cooperate with Nostrum Biodiscovery to complement the available suite of search tools for REAL Space exploration with brand-new AI-based solution for high-throughput virtual screening and hope that our synergy will allow to facilitate and strengthen the drug discovery efforts of our customers.”

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San Francisco, USA, and Kyiv, Ukraine, March 6 2023. OpenBench, the first success-driven service for small molecule hit discovery, and Enamine, the world’s leading provider of astronomical numbers of compounds for biological screening, today announced the extension of their collaboration to enrich global early discovery efforts.

Barcelona, Spain, and Kyiv, Ukraine, 15 December 2022. Pharmacelera, the leading provider of computational tools for hit discovery, and Enamine, the developer of REAL Database – the world’s largest virtual library of highly feasible compounds, have announced a partnership to jointly provide an efficient solution for hit finding. Ultra-large chemical libraries are observed as one of the key paradigms to access an unexplored chemical space. How to traverse these enormous spaces accurately is a research area that has raised the interest of the pharmaceutical industry, since finding novel hits with chemical diversity is a fundamental pillar in drug discovery.

We are excited to co-author a new article published in the journal Science: “Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor”, resulting from a fruitful international collaboration involving:

Since our return to the labs 1 month ago, we have managed to restore and catch up with practically all our synthesis and stock operations. We are extremely grateful for your being with us during these difficult times. We were happy to receive your messages of strong support and orders, demonstrating your continuous trust in Enamine. It means a lot to all of us, and it helped our quick rebirth.

Now more than 400 chemists have returned to our labs, among whom 150 as FTE’s in your research projects. Each week more chemists join back their FTE team structures. In early 2022, the company made a strategic supply of reagents and solvents so that we can continue self-sufficient synthesis activities for many months. Furthermore, most recently, significant progress has been made in receiving again goods and starting materials in Ukraine. Our newly established small synthesis lab in Latvia operates now in parallel to the Kyiv-based ones and will be happy to welcome new FTE clients.

Our parallel synthesis lab is capable now of setting up 1 400 - 1 500 syntheses per day, the rate that allows the synthesis of a few thousand REAL Compounds in a 2-month project. There is no limitation to the library size to request. As we used to encounter difficulties in dealing with the end-of-the-year REAL Compound orders always arriving in numbers, we would like to encourage you to send your requests as soon as possible and book our optimally available capacities in advance!

Enamine chemists back on creative spree. A few latest additions to our Building Block catalog

Enamine has resumed internal synthesis programs targeting to replenish and expand our catalog of Building Blocks. The strategic goal is to replicate our stock of BBs and make it evenly represented in all our three warehouses: in the US, in Latvia, and in Ukraine. The first step in this direction was made when we shipped sizeable selections of building blocks to our stocks abroad. Now our chemists are busy in resynthesizing them.

All our stock catalogs including building blocks, screening compounds, fragments, and plated compound libraries are readily available for your analysis and fully operatable. Our delivery times improve every week!

As of today, 17 countries among which France, Italy, and Austria to name a few, along with the European Union have sent their diplomats back to Kyiv, reopening their embassies, a vote of confidence that the Russia’s assault against the Ukrainian capital city and its region is over. This important symbolic and solidarity step from our allies makes clear that the necessary safety in Kyiv is returning, while the Russians have decided to re-focus on the East of Ukraine.

From our side, we are continuing working at full throttle to contribute to restoring our beloved homeland and its economy. Over 350 chemists including 100 FTE’s in our clients’ research projects have been able to resume their programs in our laboratories in Kyiv. We appreciate tremendously your indefatigable support, commitment, and trust in us!

This week we are happy to announce that our compound management team has resumed the liquid handling replication of our compound libraries. Although some more time (2 weeks) is required to fully re-start the weighing of dry compound samples from our screening collection, we can already supply from our liquid stock various pre-plated compound libraries. In line with our last week’s announcement, our very first dry-ice shipment since nearly two months has just left Kyiv towards our logistics centre in Riga from where individual orders will be further distributed to multiple clients across the world.

We are also pleased to confirm that our biology department Bienta has fully resumed its operations and provision of integrated drug discovery support. All our research facilities and technical equipment are in perfect working condition. Currently, all our groups and units (high throughput screening, bioanalytical, mass spectrometry, and in vivo) are resuming their projects and are ready to start new ones. The in vivo group is restoring the population of its laboratory animals, which were saved in our in-house core breeding section thanks to our galvanized colleagues’ efforts.

For further details, please send inquiries to This email address is being protected from spambots. You need JavaScript enabled to view it..

Faithfully Yours,
Enamine Team

Dear Colleagues, Customers, and Friends,

It has been 43 days.

Forty-three days with thousands of bombs, shells, and missiles fired out at our cities and villages, thousands of destroyed buildings, bridges, streets, thousands of killed people. And there are to be feared thousands of victims yet to come as the war continues with a new focus to the East of our country, the war for democracy to prevail against dictatorship and tyranny, the war of the civilized world against the paranoiac barbarians, the war of good against evil. Russia commits genocide against Ukrainians, terrorizes the population, and engages in looting. Nowadays after the crimes in Chernihiv and Kharkiv, after the massacre in Bucha, Irpin and Borodyanka, everybody understands: the world appears to be once again black and white these days and one can see clearly who stands on the side of Ukraine.

I am thankful to the countries and businesses that support Ukraine. I thank those of you who provide donations and help our refugees, everyone who decided to stop paying taxes and operation in Russia, and everyone who just spreads the truth and makes others aware of it. It is hard to overestimate the importance of knowing and feeling that we are not alone in our fight for freedom.

The situation in Kyiv has significantly improved and normalized for the past 2 weeks, so is the west part of our country. We are glad to see that several countries are re-opening their embassies in Kyiv. The president of the European Commission, Ursula von der Leyen, will visit Kyiv in the coming days. This shows optimal level of safety for our employees notably, and that the city returns to normal life. Following the call of our President and Prime minister to resume operations where and when it is possible, in compliance with strict safety regulations ruled by our local authorities, we, Team Enamine including already over 300 chemists, have collectively decided to get back to work in Kyiv. Indeed, gradually, since not all the chemistry can be performed right now, e.g., we avoid performing large-scale synthesis. We also expect some delays with purification and delivery for the first period, being determined to solve these issues as soon as possible with the drastically improving situation. We confirm that a major part of our synthetic operations can be performed, and that our chemists and biologists are ready and motivated to work on your projects and tasks.

Now I personally address these words to you, our valued customers and supporters. Please kindly consider resuming ordering our products and services and let us just do in that manner what we love and are best at: the synthesis. Please help us to restart the work at our full steam on custom synthesis, FTE projects and synthesis of make-on-demand building blocks. We are delighted to continue working with our established customers and are most happy to start new collaborations as we are solicitated.

Continuing ordering our compounds and services is the best support because it allows us to operate and keep our employees, our business and Ukraine strong, beside the other key reason of expediting uniquely your valuable research programs with the Art of Enamine.

Thank you!

Slava Ukraini!

Andrey Tolmachov
Founder and CEO of Enamine

Dear Customers, Dear Colleagues, Dear Friends,

The war in our country lasts more than 10 days. We have put on hold most of our operations in Kyiv and ask our customers to wait until this situation is resolved. We thank all of you for your patience. During this time, we have been able to estimate our resources, capabilities, and plan next steps to be done. Now I would like to highlight some of them:

Recursion has predicted the protein target(s) for approximately 36 billion chemical compounds in the Enamine REAL Space, reported to be the world’s largest searchable chemical library. These advances were made possible by NVIDIA DGX Cloud supercomputing and the recent acquisition of Cyclica’s MatchMaker technology.

SALT LAKE CITY, Aug. 08, 2023 (GLOBE NEWSWIRE) -- Recursion (NASDAQ: RXRX), a leading clinical stage TechBio company decoding biology to industrialize drug discovery, today announced it has successfully screened the Enamine REAL Space chemical library using its MatchMaker technology, recently acquired from Cyclica, to predict the protein target(s) for approximately 36 billion chemical compounds. This accomplishment was made possible by several other enabling discoveries, including the predicted structures derived from the AlphaFold2 database for more than 15,000 human proteins containing more than 80,000 potential binding pockets, as well as the Enamine REAL Space, which is reported to be the world’s largest searchable chemical library comprised of approximately 36 billion make-on-demand molecules. In total, this screen digitally evaluated more than 2.8 quadrillion small molecule-target pairs.

This achievement represents a significant and exciting step toward achieving our mission of decoding biology and chemistry,” said Chris Gibson, Ph.D., Co-Founder and CEO of Recursion. “Until this point, the groundbreaking progress across biology and chemistry that enabled this moment – namely, AlphaFold, the Enamine virtual chemical library and the rapid advancement of large-scale compute and new machine learning approaches – have largely lived in isolation of one another or have been bridged at relatively small scales. Leveraging Recursion’s machine learning and computational expertise and NVIDIA’s technology, we have layered these advances together to predict how each of the molecules in this vast chemical universe may interact with the protein universe.

The company generated this massive new data layer of predicted interactions in less than 90 days after closing the acquisition of Cyclica and in under 30 days since initiating the collaboration with NVIDIA.

MatchMaker uses machine learning to assess whether a small molecule is compatible with a specific protein binding pocket, providing a solution that is significantly less computationally intensive and much more scalable than traditional docking and physics-based interaction simulations. Similar to Recursion’s phenomics platform, the scalability of MatchMaker enables a “high-dimensional” view of biochemistry: activity is predicted not just for a single target, but for many at the same time. This enables three core advantages: First, this predicted data layer can be used to determine which wet-lab experiments should be executed to advance programs faster across a wide range of targets and chemical space. Second, this predicted data layer can be used as part of Recursion’s multi-modal dataset to better understand biological activity across programs quickly and at scale. Finally, this approach can pre-screen for more computationally expensive precision modeling techniques implemented by Recursion’s computational and digital chemistry teams, to more efficiently advance programs.

We are excited to collaborate with Recursion to explore the chemical space and support our mission to accelerate drug discovery,” said Andrey Tolmachev, Ph.D., Founder and Owner of Enamine. He continued: “This achievement in the 36 Billion REAL Space is just a start of our journey. The chemical knowledge accumulated at Enamine over its 35-years history allows us to explore trillions of relationships without compromising the high success rate of synthesis. We believe the predictions made by Recursion can help us prioritize parts of the chemical universe and provide an opportunity to develop focused chemical spaces and novel compounds around discovered hits quickly.

Much of the initial testing and infrastructure development for the project was completed using BioHive-1, Recursion’s in-house supercomputer, an NVIDIA DGX SuperPOD, which is ranked among the top 125 most powerful supercomputers in the world across any industry by TOP500 as of June 2023. The final analysis was made possible by NVIDIA’s DGX Cloud, an advanced AI-training-as-a-service solution to which Recursion gained access following its recently announced collaboration with NVIDIA. Recursion worked with urgency to make this effort happen in a short period of time.

Bringing together powerful data, AI and data-center scale compute, Recursion’s MatchMaker running on NVIDIA DGX Cloud essentially created a time machine for the company’s drug discovery program and sets a new bar for the industry,” said Kimberly Powell, Vice President of Healthcare at NVIDIA. “Within one week, the Recursion team was able to achieve what would have otherwise taken 100,000 years to compute with physics-based methods — setting the stage for a wet-lab, dry-lab flywheel to better predict drug-target interactions and increase a drug’s probability of success in the clinic.

Recursion plans to leverage this new database of predictions to industrialize its chemistry operations across its pipeline and in service to its partners, enabling significantly greater efficiency in its medicinal chemistry cycles. Further, Recursion plans to continue improving and expanding the number and type of chemical properties and interactions it can predict using in-house tools, tools acquired through the acquisition of Cyclica, and tools being developed by Valence Labs, the semi-autonomous research hub powered by Recursion and formed through the acquisition of Valence Discovery.

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Welcome to the latest update from Enamine - we're delighted to share our growth story with you. In our continued pursuit of scientific excellence and global expansion, we've launched a new subsidiary, Enamine Germany GmbH, based in Frankfurt's Höchst Industrial Park. This significant development strengthens our commitment to provide more localized and efficient services in organic synthesis and medicinal chemistry.

Kyiv, Ukraine, April 19, 2023 - Enamine Ltd., a provider of drug discovery services empowered with the world’s largest collections of building blocks, fragments, and screening compounds, gave an update of its long-standing research collaboration with Endogena Therapeutics AG, a clinicalstage biotech company focused on the development of endogenous regenerative medicines.

Enamine provides Endogena with its integrated capability in medicinal chemistry to support Endogena’s small molecule drug discovery programs in the fields of hit finding, hit-to-lead and lead optimization.

The companies have been collaborating under a Full Time Equivalent (FTE) model since 2019. The two discovery partners have been continuing their research collaboration to date, their research relationship not being impacted by the war in Ukraine. This collaboration extension, along with many others and new ones established by Enamine since February 24, 2022, already under the conflict, is a systematic positive trend experienced by the company, that demonstrates the support of its customers and the trust they have in receiving high-quality service backed up by the unparalleled number of diverse building blocks available at Enamine.

Sven Weiler, Vice President of Medicinal Chemistry at Endogena, commented: “The interaction with colleagues from Enamine has been a smooth one from the start. In addition to the FTE model, it is great to have access to their huge compound collection and be able to flexibly use Enamine’s capacity to its full potential. We value the output and responsiveness of the Enamine team, helping us to achieve our demanding milestones. It is stunning to see how well Enamine has been able to keep pace after February 2022.”

Michael Bossert, Head of Strategic Alliances at Enamine, added: “After 13 months of the war in the country, we are especially pleased to announce our collaboration with Endogena, a longlasting partner we have been serving during those several years with extensive medicinal chemistry and SAR efforts”.

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Kyiv, Ukraine, January 16, 2023. Enamine Ltd., the world’s leading designer and supplier of screening compound libraries and building blocks, together with UORSY, a top Ukrainian chemical company producing products for early drug discovery, announced today the creation of a joint “Legacy” screening collection.

This morning, russia carried out another act of aggression, firing dozens of rockets at peaceful cities in Ukraine, including Kyiv. Another act of barbarian terrorism. Despite it, we stand firm and resilient.

We are glad to inform you that we have fully restored the scope of our building block catalog as it was before the 24^th of February war outbreak. The catalog lists over 238 000 off-the-shelf products. Such items are again offered in the various batch sizes reaching up to 100 grams in many cases to give you full scale of choice for your projects. Please visit https://enaminestore.com/catalog to make structure searches and order online.

We are happy to inform you that we have successfully completed the relocation of our entire collection of screening compounds and started weighing compound samples since yesterday. All 3.5 million vials with dry compounds have been safely moved to our new facility in Sokal, a town near Lviv with a population of 20 000 people in the West of Ukraine, close to the Polish border.

The situation in Kyiv keeps improving day by day, shops and restaurants are re-opening and people are returning to their homes in a continuous stream. More and more chemists come back to their labs and resume their projects at Enamine. Currently, over 300 chemists are already back to work, and we estimate this number to grow up to 400-500 colleagues within the next couple of weeks. We have restored the synthesis of building blocks, REAL Compounds, as well as custom synthesis, including FTE research projects in our Kyiv’s facility. Along with our absolute capacity to resynthesize building blocks in larger amounts as before, the resumption of the supplies from Ukraine has allowed us to return 2.5-, 5-, and 10-gram amounts to our building block catalog. Following our contingency plan at the war outbreak, we completely switched to supplies from our warehouses in US and Latvia, both largely limited to the 1-gram batch size. Now, we are resuming supplies of the larger amounts from our Kyiv stock and via resynthesis! Please check our offer at https://enaminestore.com/.

The quick supply of the building blocks is crucial. Even though the infrastructure in Ukraine has been significantly damaged during the war and despite express courier services have been suspended for the time being, our logistics specialists have organized a 3-day ground transportation route from Kyiv to our EU-based site in Latvia. This means that delivery time from Ukraine to your lab will be cut down to around 7-10 days very soon. Delivery time from US and EU local stores is as always 1-2 days.

We are looking forward to receiving your new inquiries and orders! This is the best way you can help us.

Faithfully Yours,
Enamine Team

We, at Enamine, have united to resist at our level the Russian invasion. We help to acquire non-lethal military aid to enhance defence of Ukraine, provide medical supplies to the hospitals, provide sponsorship for science and education in Ukraine, and help our employees scattered by war across Ukraine and abroad. Our own funds are limited as we have had to put on hold most of our projects and we will greatly appreciate your donations, which we will immediately use for the urgent needs of today! This is the most direct help to Ukraine.

Please use correct currency accounts and indicate the purpose of payment as “charitable assistance”.

In order to track your donation please inform us about it by email: This email address is being protected from spambots. You need JavaScript enabled to view it.. If you have any particular purpose of donation (e.g. “medicines”, “social help”) please indicate it in your email. Please also contact us by email if you have any questions about the fund.

Thank you for your support!

Dear Customers, Dear Colleagues, Dear Friends, 

When I started the company after the USSR collapse there were just a couple of labs in the academic institute. Nowadays my company is well known around the world.