- Partnering supports novel DEL-screening capabilities
- Chemspace and Enamine positioned to augment product and service offerings
- Orogen to gain potential novel therapeutic small molecules
WOBURN, MA, USA - KYIV, UKRAINE - July 16, 2025 — Orogen Therapeutics, Inc., a private drug discovery company utilizing its proprietary, AI-enabled DNA encoded library (DEL) technology to identify novel chemical matter against medically and commercially attractive drug targets, Chemspace, LLC, an expert in the generation and exploration of ultra-large chemical datasets, and Enamine, Ltd., a leading worldwide provider of chemical compounds and drug discovery services, announced today a strategic collaboration to design, build, and test novel DNA-encoded libraries (DEL) leveraging Chemspace’s chemi-informatics and synthetic capabilities and Enamine’s REAL design principles, combined with Orogen’s deep DEL expertise, and proprietary AI- and DEL-enabled small molecule drug discovery capabilities.
Enamine’s REAL compounds are the world’s largest collection of make-on-demand small molecules that represents a significant fraction of the synthetically accessible chemical space. Its member molecules are REadily AccessibLe through validated parallel synthesis protocols using qualified in-stock building blocks. Orogen’s DEL- and AI-enabled platform, including FocusDEL™ technology, enables rapid, efficient drug screening of billions of chemically diverse compounds to effectively home in on small drug-like molecules against specific targets from a wide range of therapeutic areas and clinical indications.
We are thrilled to engage in this strategic collaboration to drive new horizons for DEL-based drug by combining Chemspace’s expertise in ultra-large chemical datasets, Enamine’s unparalleled REAL Space of innovative chemical matter, and Orogen’s AI- and DEL-enabled small molecule drug discovery platform - to advance a new generation in DEL capability,
stated Mark Pykett, Orogen CEO. We are excited by the potential synergy of the two platforms to enhance and accelerate small molecule drug discovery.
DNA-encoded library (DEL) screening offers a proven valuable alternative for sampling large chemical space for efficient small molecule drug discovery,
stated Sven Wagner, PhD, Vice President of Partnerships at Enamine. We are pleased to contribute Enamine’s large and rapidly synthesizable REAL Space to this collaboration with Orogen, leveraging AI-enabled DELs. Our dovetailing joint effort will enrich DEL-based drug R&D with a critical component and a large part of chemical space, ready to be mined by researchers around the world, ultimately to enable sooner than later treatments for patients with high unmet needs across therapeutic areas, such as immuno-inflammatory disorders.
Under the terms of the collaboration, Chemspace and Orogen will design novel DELs in alignment with the REAL Space foundational principles; Chemspace and Enamine will synthesize and analytically validate these REAL-driven DELs, and Orogen will screen pilot DELs against multiple biological targets. Chemspace and Enamine anticipate the opportunity to provide these libraries to enhance their array of product and service offerings, while Orogen envisions opportunities for multiple novel small molecule candidates aligned with its areas of focus in immuno-inflammatory disorders, GPCRs, and select oncology targets.
Artem Evdokimov, PhD, Orogen’s head of research, noted, We anticipate this collaboration will add a set of much-needed next-generation DELs to the arsenal of early drug discovery tools. Harmonization of DEL designs with REAL space chemistry enables rapid follow-up on screening: off-DNA compounds and thousands of their SAR-expanding chemical space neighbors can be made both expeditiously and economically – accelerating the early discovery process for much-needed novel, safe, and effective medicines.
Olga Tarkhanova, PhD, CEO of Chemspace: DEL technology is a powerful approach for efficiently exploring vast chemical space, enabling rapid hit identification, structure-activity relationship (SAR) development, and the discovery of novel binding sites. We are excited to join forces with Orogen, a leader in DEL-based drug discovery, and to integrate Chemspace’s expertise in cheminformatics and synthesis with Enamine’s REAL Space concept for next-generation DEL design. With this collaboration, we bring the benefits of scalable, make-on-demand combinatorial chemistry to the DEL field, addressing a key bottleneck in moving from encoded hits to optimized compounds. By applying the REAL Space concept to DELs and integrating our proven Make-On-DEmand chemistry, this collaboration aims to simplify off-DNA hit synthesis and optimization, accelerate DMTA (design–make–test–analyze) cycles, and help advance new therapies.