Electrophilic Covalent Probe Library
Characterized by a new HTS thiol-reactivity assay
960 compounds
Electrophilic Covalent Probe Library is aimed at the discovery of new inhibitors for cysteine-containing proteins. The library was developed by our collaborators at Weizmann Institute of Science (WIS), London lab and XChem group at Diamond Light Source. The design process of this library is described in the paper. All fragments were evaluated for thiol-reactivity and screened against 10 cysteine-containing proteins.
We refined a set of molecules initially proposed in the paper by removing compounds found to be promiscuous binders or highly reactive in the screening of several proteins.
Typical Formats
Catalog No.
ECPL-960-10-Y-100
Compounds
960 3 plates
Amount
10 µL of 100 mM DMSO solutions
Plates and formats
384-well plates Greiner Cat. No 781280, first two and last two columns empty, 320 cpds per plate
Price
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Catalog No.
ECPL-960-25-Y-20
Compounds
960 3 plates
Amount
25 µL of 20 mM solutions in DMSO
Plates and formats
384-well plates, 1,2 & 23,24 columns empty, 320 compounds per plate
Price
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Catalog No.
ECPL-960-50-Y-20
Compounds
960 3 plates
Amount
50 µL of 20 mM solutions in DMSO
Plates and formats
384-well microplates, Greiner Cat. No 782270, 1, 2, 3 and 4 columns empty, 320 compounds per plate
Price
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Catalog No.
ECPL-960-100-X-20
Compounds
960 12 plates
Amount
100 µL of 20 mM solutions in DMSO
Plates and formats
96-well plates, Greiner Cat. No 651201, 1 & 12 columns empty, 80 compounds per plate
Price
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Catalog No.
ECPL-960
Compounds
960
Amount
Custom
Plates and formats
Any custom format
Price
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Download SD files
Key features
- Experimentally evaluated
- No over reactive and promiscuous covalent binders
- Initial SAR data based on small clusters
- Ease of chemistry for fast follow-up
For most convenient and fast delivery Electrophilic covalent probe library is available in versatile pre-plated formats and can be delivered within a week only! This library has also been evaluated for stability in DMSO and storage in solutions for at least 2 years.
Representative examples of cluster centroid molecules
Molecular properties
