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Characterized by a new HTS thiol-reactivity assay

960 compounds

Electrophilic Covalent Probe Library is aimed at the discovery of new inhibitors for cysteine-containing proteins. The library was developed by our collaborators at Weizmann Institute of Science (WIS), London lab and XChem group at Diamond Light Source. The design process of this library is described in the paper. All fragments were evaluated for thiol-reactivity and screened against 10 cysteine-containing proteins.

We refined a set of molecules initially proposed in the paper by removing compounds found to be promiscuous binders or highly reactive in the screening of several proteins.

Typical Formats

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

ECPL-960-10-Y-100

Compounds

960
3 plates

Amount

10 µL of 100 mM DMSO solutions

Plates and formats

384-well plates Greiner Cat. No 781280, first two and last two columns empty, 320 cpds per plate

Price

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Catalog No.

ECPL-960-25-Y-20

Compounds

960
3 plates

Amount

25 µL of 20 mM solutions in DMSO

Plates and formats

384-well plates, 1,2 & 23,24 columns empty, 320 compounds per plate

Price

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Catalog No.

ECPL-960-50-Y-20

Compounds

960
3 plates

Amount

50 µL of 20 mM solutions in DMSO

Plates and formats

384-well microplates, Greiner Cat. No 782270, 1, 2, 3 and 4 columns empty, 320 compounds per plate

Price

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Catalog No.

ECPL-960-100-X-20

Compounds

960
12 plates

Amount

100 µL of 20 mM solutions in DMSO

Plates and formats

96-well plates, Greiner Cat. No 651201, 1 & 12 columns empty, 80 compounds per plate

Price

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Catalog No.

ECPL-960

Compounds

960

Amount

Custom

Plates and formats

Any custom format

Price

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Download SD files

Electrophilic Covalent Probe Library

Library code: ECPL-960

Version: 14 October 2022

960 compounds

Key features

  • Experimentally evaluated
  • No over reactive and promiscuous covalent binders
  • Initial SAR data based on small clusters
  • Ease of chemistry for fast follow-up

For most convenient and fast delivery Electrophilic covalent probe library is available in versatile pre-plated formats and can be delivered within a week only! This library has also been evaluated for stability in DMSO and storage in solutions for at least 2 years.

Representative examples of cluster centroid molecules

Molecular properties

 

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