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Electrophilic Covalent Probe Library

Characterized by a new HTS thiol-reactivity assay

960 compounds

Electrophilic Covalent Probe Library is aimed at the discovery of new inhibitors for cysteine-containing proteins. The library was developed by our collaborators at Weizmann Institute of Science (WIS), London lab and XChem group at Diamond Light Source. The design process of this library is described in the paper. All fragments were evaluated for thiol-reactivity and screened against 10 cysteine-containing proteins.

We refined a set of molecules initially proposed in the paper by removing compounds found to be promiscuous binders or highly reactive in the screening of several proteins.

Key features

  • Experimentally evaluated
  • No over reactive and promiscuous covalent binders
  • Initial SAR data based on small clusters
  • Ease of chemistry for fast follow-up

For most convenient and fast delivery Electrophilic covalent probe library is available in versatile pre-plated formats and can be delivered within a week only! This library has also been evaluated for stability in DMSO and storage in solutions for at least 2 years.

Most popular library formats available for immediate supply

Catalog ID
Compounds
Amount
Format
Price

Catalog ID

ECPL-960-10-Y-100

Compounds

960
3 plates

Amount

10 µL of 100 mM DMSO solutions

Plates and formats

384-well plates Greiner Cat. No 781280, 320 cpds per plate, first two and last two columns empty

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Catalog ID

ECPL-960-25-Y-20

Compounds

960
3 plates

Amount

25 µL of 20 mM solutions in DMSO

Plates and formats

384-well plates, 320 compounds per plate 1,2 & 23,24 columns empty

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Catalog ID

ECPL-960-50-Y-20

Compounds

960
3 plates

Amount

50 µL of 20 mM solutions in DMSO

Plates and formats

384-well microplates, Greiner Cat. No 782270, 320 compounds per plate, 1, 2, 3 and 4 columns empty

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Catalog ID

ECPL-960-100-X-20

Compounds

960
12 plates

Amount

100 µL of 20 mM solutions in DMSO

Plates and formats

96-well plates, Greiner Cat. No 650160, 80 compounds per plate, 1 & 12 columns empty

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Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

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Representative examples of cluster centroid molecules

Molecular Properties

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