Fluorinated Fragment Library

Specially designed for 19F NMR ligand-based screening

6 377 compounds

Enamine holds expertise in organofluorine chemistry with over 50 scientific papers in this research area published in the last 10 years. Our chemists are heavily involved in research on new synthetic methodologies for introducing fluorine atoms into a wide range of aliphatic/aromatic heterocyclic cores and various side chains.

The fragment selection has been made with emphasis on high structural quality of molecules and easy performance and interpretation of 19F NMR screening results. Very simple/trivial cores with overused chemistry; compounds having more than two stereocenters, showing rotamers, diastereoisomeric mixtures, as well as molecules prone to aggregation have been removed from the set.


Get more details

Download SD files

Fluorinated Fragments

6 377 compounds for cherry-picking

Fluorinated Fragments Diversity Set

Library code: FDS-1000

Version: 21 May 2021

1 000 compounds

Fluorinated Fragments Diversity Set 2020

Library code: FFL-d6

Version: 21 May 2021

1 280 compounds

Key features

  • Experimentally confirmed solubility in PBS buffer at 1 mM, in DMSO at 200 mM
  • 19F NMR chemical shifts are provided for all compounds in aqueous PBS or DMSO solutions.
  • Full Ro3 compliance, no reactive and unstable compounds, stability in DMSO solution has been tested.
  • 15 200 in-stock analogues are available (MW 160…400)
  • Cherry-picking is possible; delivery in any custom format including dry powders or DMSO solution in vials, microtubes or plates within 1–3 weeks

Examples of the molecules in the library

Single-fluorine Fragments


Difluoromethyl-substituted Fragments


Trifluoromethyl-substituted Fragments


Contact us

I have read and agree with Privacy Policy of Enamine

Send me details