Source of biologically validated starting points
4 160 compounds
Screening of natural products has inspired discovery of remarkable number of drugs. Enrichment of small libraries with compounds possessing structural motifs validated by nature allows reaching better molecular profile and improves biological response. A special place in drug development should belong to Natural Product-like Fragments as promising starting points within attractive chemicals space.
Typical Formats
Catalog No.
NPL-4160-Y-10
Compounds
4 16013 plates
Amount
10 µL of 10 mM DMSO stock solutions
Plates and formats
384-well microplates, first two and last two columns empty, 320 compounds per plate
Price
Catalog No.
NPL-4160-X-50
Compounds
4 16052 plates
Amount
50 µL of 100 mM DMSO stock solutions
Plates and formats
96-well plates, Greiner, first and last columns empty
Price
Catalog No.
NPL-4160-X-100
Compounds
4 16052 plates
Amount
100 µL of 10 mM DMSO stock solutions
Plates and formats
96-well microplates, 80 compounds per plate
Price
Catalog No.
NPL-4160
Compounds
4 160
Amount
Custom
Plates and formats
Any custom format
Price
Download SD file
Library code: NPL-4160
Version: 23 February 2024
4 160 compounds
at 100 mM in DMSO
Key features
- Scaffold Tree approach was applied to the Universal Natural Product Database (UNPD) comprising over 200K compounds to extract initial Scaffold Set.
- MedChem structural filters and refinements were used in order to remove trivial chemotypes, PAINS and overpopulated cores resulting in the Reference Scaffold Set with 550 structures.
- Substructure and similarity searches were applied to extract compounds bearing natural-like cores and moieties. Scaffold frequency analysiswas carried out to finalize and optimize fragment library.
Examples of the molecules
Vindoline
Ajmaline
