More than 20 FDA-approved drugs contain the morpholine moiety, although it is often metabolically labile. Morpholine-based analogues may advantageously alter important pharmacokinetic properties such as lipophilicity and metabolic stability when grafted onto molecular scaffolds. Herein we have designed and synthesized a library of morpholine analogues for drug design.
Design
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>100 unique morpholine analogues on a 5-50 g scale from stock.
