gem-Difluorinated Amines for Drug Design

Fluorinated derivatives play an important role in medicinal chemistry. The selective incorporation of a fluoroalkyl group into bioactive compounds often affects their binding affinity, metabolic stability, lipophilicity, membrane permeability and bioactivity. gem-difluoromethylene group (CF2) is a valuable fluorinated motif that is present in pharmaceuticals and biologically active compounds. In particular, gem-CF2-group improves ADME- and PK-properties. In this context, Enamine offers a library of unique difluoro-substituted cyclic amines for drug design.

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>100 gem-difluorinated amines on gram-scale from stock.


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