Sulfoximines for Drug Design
Incorporation of a sulfoximine group into bioactive compounds often improves their ADME/Tox profile, and enhances potency. Moreover, the moiety of sulfoximine is chemically and metabolically stable. NH-sulfoximines can serve as the both hydrogen bond donors and acceptors at the same time. Production and commercialization of the building blocks that already contain a sulfoximine group allow significant accelerating discovery of drug candidates. Herein we have designed and synthesized a library of sulfoximines for drug design.
Unique properties:↑ chemical stability; ↑ metabolic stability; ↑ aqueous solubility.
>100 unique sulfoximines on a 5-50 g scale from stock.