Due to their small size and low polarity, oxetanes have become a widespread motif in modern drug discovery. Fluorination of oxetanes can further reduce their lipophilicity and alter the electronic properties of neighboring groups, impacting pKa transition values and the ability to form donor-acceptor interactions with protein targets. Explore Enamine's collection of 3-fluoro- and 3,3-difluorooxetane building blocks to fine-tune the desired properties of pharmacological molecules.
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Over 25 fluorooxetanes from stock on 5-10 gram scale
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Fluorooxetanes that are ready to be synthesized upon request.
