Covalent Screening Library

The largest and most reliable source of Covalent Modifiers
88 317 compounds in stock

Diverse Covalent Library with most demanded warhead types

11 200 compounds

Covalent screening became an integral part of Drug Discovery process. Covalent probes play essential role in discovery of new technologies, investigation of new proteins and assessment of their drugability.

A number of successful examples, when converting lead molecule to covalent binders leads to increase of overall efficacy, acknowledged this approach as a powerful tool for medicinal chemists.

Enamine focused on elaboration of parallel synthesis approaches to synthesize series of new valuable covalent compounds with well-working and not over reactive warheads. All our efforts resulted in production of the largest commercially available Collection of Covalent Compounds. Most interesting covalent classes were assembled into diverse Library, aimed to represent Enamine’s Covalent Collection.

The Library available pre-plated at 10 mM concentration in DMSO. Each covalent binder type is plated in the separate plates.

Library can be supplied in multiple formats including the following options:

Catalog No.
Compounds
Amount
Format
Price

Catalog No.

Covalent Screening Library
CSL-11200-5-Z-10

Compounds

11 200
9 plates

Amount

5 μL of 10 mM DMSO solutions

Plates and formats

1536-well acoustic LDV microplates, Labcyte #LP-0400; first and last four columns empty;
1280 compounds per plate

Price

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Catalog No.

Acrylamide Screening sublibrary
CSAC-4080-50-X-10

Compounds

4 080
51 plates

Amount

50 μL of 10 mM DMSO solutions

Plates and formats

96-well plates, Greiner #650201;
1 and 12 columns empty;
80 compounds per plate

Price

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Catalog No.

Chloroacetamide sublibrary
CSCL-1200-25-Y-10

Compounds

1 200
4 plates

Amount

25 μL of 10 mM DMSO solutions

Plates and formats

384-well plates, Greiner #784201;
1, 2 and 23, 24 columns empty;
320 compounds per plate

Price

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Catalog No.

2-Chloropropionamide sublibrary
CSCP-560-10-Y-10

Compounds

560
2 plates

Amount

10 µL of 10 mM DMSO solutions

Plates and formats

384-well LDV plates, Labcyte #LP-0200,
1, 2 and 23, 24 columns empty,
320 compounds per plate

Price

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Catalog No.

Vinyl Sulfone sublibrary
CSVS-960-50-X-10

Compounds

960
3 plates

Amount

50 µL of 10 mM DMSO solutions

Plates and formats

96-well plates, 2D-barcoded Matrix microtubes #4271,
1 and 12 columns empty,
80 cmpds per plate

Price

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Catalog No.

Cyanacrylamide sublibrary
CSCA-1760-40-X-10

Compounds

1 760
22 plates

Amount

40 µL of 10 mM DMSO solutions

Plates and formats

96-well plates, Greiner #650201,
1 and 12 columns empty,
80 compounds per plate

Price

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*Please request for any other format or compounds pooling. We will be happy to deliver our libraries in any convenient for your project formats.

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Key features

  • Careful choice of warheads: only experimentally confirmed, well-validated and reported in number of papers.
  • Compounds plated by classes for ease of reactivity analysis and residue-focusing screening campaigns.
  • Novel compounds featuring new chemistry and the latest Enamine core Building Blocks.

Distribution by covalent warheads

Examples of covalent binders in the library

**Please note that Boronics and Sulfonyl fluorides may not give the exact molecular ion in mass spectra.
Boronic acids require addition of 1-1.5% of water for LCMS spectra.

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