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Diverse covalent library with most demanded warhead types

11 760 compounds

Covalent probes play an essential role in the discovery of new technologies, investigation of new proteins, and assessment of their drugability. We at Enamine have been working since 2016 on synthesis on covalent compounds and development of new covalent warheads.

Enamine focused on the elaboration of parallel synthesis approaches to synthesize a series of new valuable covalent compounds with well-working and not overreactive warheads. All our efforts resulted in the production of the largest commercially available Collection of Covalent Compounds. Most interesting and popular covalent classes were assembled into a diverse Library, aimed to represent Enamine’s Covalent Collection.

The Library is available in pre-plated format at 10 mM concentration in DMSO. Each covalent binder type is plated in separate plates.

Typical Formats

Covalent Screening Library is available for supply in various pre-plated formats, including the following most popular ones:

Catalog No.
Compounds
Amount
Format*
Price

Catalog No.

Covalent Screening Library
CSL-11-0-Z-10

Compounds

11 760
10 plates

Amount

≤ 300 nL of 10 mM of DMSO solutions

Plates and formats

1536-well Echo LDV microplates, first and last four columns empty, 1280 compounds per plate

Price

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Catalog No.

Covalent Screening Library
CSL-11-10-Y-10

Compounds

11 760
37 plates

Amount

10 µL of 10 mM DMSO solutions

Plates and formats

384-well, Echo Qualified LDV microplates #001-12782 (LP-0200), first and last two columns empty, 320 compounds per plate

Price

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Catalog No.

Covalent Screening Library
CSL-11-50-Y-10

Compounds

11 760
37 plates

Amount

50 μL of 10 mM DMSO solutions

Plates and formats

384-well, Greiner Bio-One plates #781280, first and last two columns empty, 320 compounds per plate

Price

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Catalog No.

Acrylamides
CSAC-4160-20-Y-10

Compounds

4 160
13 plates

Amount

20 μL of 10 mM DMSO solutions

Plates and formats

384-well plates, Greiner #765021, 1, 2 and 23, 24 columns empty, 320 compounds per plate

Price

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Catalog No.

Cyanacrylamides
CSCN-1920-10-Y-10

Compounds

1 920
6 plates

Amount

10 µL of 10 mM DMSO solutions

Plates and formats

384-well echo LDV plates, #LP-200, 1,2 and 23,24 columns empty, 320 compounds per plate

Price

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Catalog No.

Chloroacetamides
CSCL-1200-25-Y-10

Compounds

1 200
4 plates

Amount

25 μL of 10 mM DMSO solutions

Plates and formats

384-well plates, Greiner #784201, 1, 2 and 23, 24 columns empty, 320 compounds per plate

Price

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Catalog No.

Vinyl Sulfones
CSVS-640-50-X-10

Compounds

640
2 plates

Amount

50 µL of 10 mM DMSO solutions

Plates and formats

96-well plates, 2D-barcoded Matrix microtubes #4271, 1 and 12 columns empty, 80 cmpds per plate

Price

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Catalog No.

Formyl Boronates
FBA-480-15-Y-10

Compounds

480
2 plates

Amount

15 µL of 10 mM DMSO solutions

Plates and formats

384-well echo plates, Labcyte #PP-0200, 1,2 and 23,24 columns empty, 320 compounds per plate

Price

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*We will be happy to provide our library in any other most convenient for your project format. Please select among the following our standard microplates: Greiner Bio-One 781270, 784201, 781280, 651201 or Echo Qualified 001-12782 (LP-0200), 001-14555 (PP-0200), 001-6969 (LP-0400), C52621 or send your preferred labware. Compounds pooling can be provided upon request.

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Covalent Screening Library

Library code: CSL-11760

Version: 27 October 2023

11 760 compounds

Acrylamide Screening Library

Version: 20 February 2023

4 160 compounds

 

Chloroacetamide Screening Library

Version: 27 October 2023

1 200 compounds

 

Sulfonyl Fluoride Screening Library

Version: 23 February 2023

640 compounds

 

Vinyl Sulfones Screening Library

Version: 20 February 2023

640 compounds

Cyanacrylamides Screening Library

Version: 20 February 2023

1 920 compounds

Formyl Boronates Screening Library

Version: 6 February 2023

480 compounds

Chloropropionamides Screening Library

Version: 13 February 2023

560 compounds

Key features

  • Careful choice of warheads: only experimentally confirmed, well-validated, and reported in the number of papers. No overreactive binders.
  • All compounds in the library feature a certain chemotype, “recognition pattern”, to avoid promiscuous bindings.
  • Compounds plated by classes for ease of reactivity analysis and residue-focusing screening campaigns.

Examples of molecules in the library

Distribution by covalent warheads

 

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