Covalent Screening Library
Diverse covalent library with most demanded warhead types
11 760 compounds
Covalent probes play an essential role in the discovery of new technologies, investigation of new proteins, and assessment of their drugability. We at Enamine have been working since 2016 on synthesis on covalent compounds and development of new covalent warheads.
Enamine focused on the elaboration of parallel synthesis approaches to synthesize a series of new valuable covalent compounds with well-working and not overreactive warheads. All our efforts resulted in the production of the largest commercially available Collection of Covalent Compounds. Most interesting and popular covalent classes were assembled into a diverse Library, aimed to represent Enamine’s Covalent Collection.
The Library is available in pre-plated format at 10 mM concentration in DMSO. Each covalent binder type is plated in separate plates.
Typical Formats
Catalog No.
Covalent Screening Library
CSL-11760-5-Z-10
Compounds
11 760
10 plates
Amount
5 μL of 10 mM DMSO solutions
Plates and formats
1536-well acoustic LDV microplates, Labcyte #LP-0400, first and last four columns empty, 1280 compounds per plate
Price
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Catalog No.
Acrylamides
CSAC-4160-20-Y-10
Compounds
4 160
13 plates
Amount
20 μL of 10 mM DMSO solutions
Plates and formats
384-well plates, Greiner #765021, 1, 2 and 23, 24 columns empty, 320 compounds per plate
Price
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Catalog No.
Cyanacrylamides
CSCN-1920-10-Y-10
Compounds
1 920
6 plates
Amount
10 µL of 10 mM DMSO solutions
Plates and formats
384-well echo LDV plates, #LP-200, 1,2 and 23,24 columns empty, 320 compounds per plate
Price
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Catalog No.
Chloroacetamides
CSCL-1200-25-Y-10
Compounds
1 200
4 plates
Amount
25 μL of 10 mM DMSO solutions
Plates and formats
384-well plates, Greiner #784201, 1, 2 and 23, 24 columns empty, 320 compounds per plate
Price
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Catalog No.
Vinyl Sulfones
CSVS-640-50-X-10
Compounds
640
2 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
96-well plates, 2D-barcoded Matrix microtubes #4271, 1 and 12 columns empty, 80 cmpds per plate
Price
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Catalog No.
Formyl Boronates
FBA-480-15-Y-10
Compounds
480
2 plates
Amount
15 µL of 10 mM DMSO solutions
Plates and formats
384-well echo plates, Labcyte #PP-0200, 1,2 and 23,24 columns empty, 320 compounds per plate
Price
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Catalog No.
Covalent Screening Library
CSL-11760
Compounds
11 760
Amount
Custom
Plates and formats
Any custom format
Price
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Download SD files
Key features
- Careful choice of warheads: only experimentally confirmed, well-validated, and reported in the number of papers. No overreactive binders.
- All compounds in the library feature a certain chemotype, “recognition pattern”, to avoid promiscuous bindings.
- Compounds plated by classes for ease of reactivity analysis and residue-focusing screening campaigns.
Examples of molecules in the library
Distribution by covalent warheads
