Innovatively designed and experimentally confirmed library for reliable enantioselective ASMS screening
12 642 compounds
Rapid progress in drug discovery depends on the continuous development of innovative technologies and advanced screening approaches. Tackling challenging targets and so‑called “undruggable” proteins requires not only novel techniques and screening methods but also access to high‑quality, well‑characterized compound libraries.
The recently introduced enantioselective protein affinity selection mass spectrometry (E‑ASMS, Nature Comm. 2025) approach streamlines the time needed for hit identification and hit validation. This method accelerates early drug discovery by enabling the detection of weak binders, delivering critical insights into compound selectivity, and providing orthogonal confirmation of binding events — all without reliance on traditional counter‑screen assays. When combined with carefully designed compound library, E‑ASMS offers a powerful platform for fast identification of promising therapeutic leads.
In collaboration with leading experts from top Pharma companies and the Structural Genomics Consortium (SGC), we carefully designed, experimentally characterized, and validated — through numerous screening campaigns — the first edition of our Enantio‑ASMS Library (E‑ASMS).
Typical Formats
E-ASMS Library is available for supply in various pre-plated, including but not limited to the following most popular ones:
Catalog No.
E-ASMS-12642-Y-10
Compounds
12 642
40 plates
Amount
10 µL of 10 mM DMSO solutions
Plates and formats
384-well echo-source plates, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
E-ASMS-12642-Y-25
Compounds
12 642
40 plates
Amount
25 µL of 10 mM DMSO solutions
Plates and formats
384-well plates, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
E-ASMS-12642-X-25
Compounds
12 642
158 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
96-well plates, 80 compounds per plate, 1 and 12 columns empty
Price
*Please select among the following standard microplates: Greiner Bio-One 781270, 784201, 781280, 651201 or Echo Qualified 001-12782 (LP-0200), 001-14555 (PP-0200), 001-6969 (LP-0400), C52621 or send your preferred labware. Compounds pooling can be provided upon request.
Plated librarie in stock:
Library Design
E-ASMS Library has been developed to accelerate the early stages of drug discovery by providing a diverse and well-characterized set of small molecules. Each compound has been selected to have only one chiral atom and be a mixture of only two enantiomers, which can be easily separated by using one of four standard and described in the paper conditions.
Additionally, the library is designed to maximize chemical space coverage, maintain drug‑like properties, and support efficient hit identification across diverse therapeutic areas. Rigorous quality control and SFC chiral separation of each compound ensures reproducibility and reliability, making this library a robust resource for screening campaigns.
UMap projection to the entire enamine stock collection of 4.6 million compounds and PMI plot.
Each compound in the library is supported with pre-calculated analogs from stock and from REAL Space. Links to the files with calculated analogs are available from SD file in a separate column.
Analogs calculation and search in REAL Space
1. Reaction guided search of analogs
2. Synthon-based sub-structure search
We invite medicinal chemists, biologists, and drug hunters to integrate the E-ASMS Library into their discovery pipelines. By leveraging this curated library, researchers can rapidly identify novel scaffolds, explore structure activity relationships, and generate data that informs lead optimization process. Contact us today to access the library and accelerate your next breakthrough.
Molecular properties
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
