CLOUD

To date no commercially available compound collection covered all drug classes, resulting in complications in combinatorial screening attempts. We collaborated with a group of researchers at CeMM and collected a condensed screening set of 299 small molecules representing the entire target and chemical space of all FDA-approved drugs. The CeMM Library of Unique Drugs (CLOUD) covers prodrugs and active forms at pharmacologically relevant concentrations and is ideally suited for combinatorial studies. Recent publication [1] provides evidences of successful drug repurposing by pairwise compound screening from CLOUD collection in cancer cell viability assay. The findings highlight that refined chemical library CLOUD is a powerful tool for drug repurposing and evaluation of new substances suitable for all high-content and high-throughput assays.

Key features

• Covers all therapeutically significant space of approved drugs.
• Contains prodrugs and active metabolites at pharmacologically relevant concentrations.
• Ideally applicable for combinatorial assays to study new drug combinations.
• Most structurally diverse drug library among commercially available collections.
• Immediately accessible in convenient pre-plated formats with carefully prepared detailed documentation. The library can be also made in any customized ready-to-screen formats.

Examples of drugs in the library

Selection and library evolution scheme

[1] Nature Chemical Biology 13, 771–778 (2017).