Ion Channel Library
Designed for discovery of new Ion Channels ligands
36 800 compounds
Ion channels are most widely distributed in organism tissues and play an important role in numerous cell types as large families of related genes with cell-specific expression pattern. This type of therapeutic targets is most important in developing of new highly effective medical treatments in the same time being one of the most difficult tasks in Medicinal Chemistry.
Examples of the molecules
Using our Libraries for hit identification you receive multiple benefits allowing you to save on time and costs in lead generation:
- Resupply from dry powders for hit confirmation, hit expansion from in-stock analogs.
- Straightforward and low-cost synthesis of analogues through our REAL Database technology.
- Medicinal chemistry support enhanced with on-site broad ADME/T panel.
Most popular library formats
36 800 115 plates
≤ 300 nL of 2 mM solutions in DMSO
384-well small volume plates, Greiner Cat. No. 784201; 320 compounds per plate 1, 2 & 23, 24 columns empty
36 800 29 plates
5 µL of 10 mM DMSO stock solutions
1536-well microplates, Echo Qualified, 1280 compounds per plate, first four and last four columns empty
36 800 115 plates
25 µL of 10 mM DMSO solutions
384-well microplates, 320 compounds per plate, first two and last two columns empty
Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.
We applied multipronged approach in rational library design to gain a qualitative set of molecules focused on ion channel targets. A major contribution was made in the lead-oriented synthesis program at Enamine focused on increasing novelty and structural diversity. The project has already yielded 36 800 lead-like compounds built on novel scaffolds featuring saturated rings that have been recognized as potential ion channel blockers. Pharmacophore ligand-based biased analysis was performed on the reference set of over 1 000 highly active ligands (≤10 nM) resulting in three main pharmacophore motifs frequently occurring in reported ligands. Optimized models were used in searching a lead-like part of Enamine Screening Collection and a lead-like part of, REAL database. One of the common features of derived pharmacophores was presence of tertiary/secondary amino group. Additional compounds were added to the library after analysis of privileged motives of known ion channel blockers and after morphing of some recently discovered ion channel and TRPV1 modulators. General Medicinal Chemistry overview finalized the library profile: favorable physicochemical parameters and solubility requirements.