Discovery Diversity Set

Top-quality diverse library of recently synthesized compounds

50 240 compounds

The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Compound screening libraries nowadays must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live chemistry” that can supply related chemical entities.

Enamine is constantly updating its Screening catalog with at least 100,000 newly synthesized compounds each year. These molecules are built on novel chemistry with use of the latest achievements in parallel chemistry and following industry trends in molecular properties and structural features. Every new library to be synthesized went through serial filters and is focused to bring novelty in a certain drug discovery area.

Discovery Diversity Sets (DDS) are aimed to bring latest chemistry to our customers within a smart clustering approach. Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three main screening collections – HTS, Advanced, and Premium.

Most popular library formats

Catalog ID
Compounds
Amount
Formats
Price

Catalog ID

DDS-50-0-Z-2

Compounds

50 240
40 plates

Amount

≤ 300 nL of 2mM DMSO solutions

Plates and format

1536-well microplates, Echo Qualified, Labcyte #LP-0400, 1280 compounds per plate, first four and last four columns empty

Catalog ID

DDS-50-10-Y-10

Compounds

50 240
157 plates

Amount

10 µL of 10 mM DMSO solutions

Plates and format

384-well plates, Greiner #784201, 320 compounds per plate, 1,2 & 23,24 columns empty

Catalog ID

DDS-50-25-Y-10

Compounds

50 240
143 plates

Amount

25 µL of 10 mM DMSO solutions

Plates and format

384-well acoustic plates, Labcyte #PP-0200, last two columns empty, 352 compounds per plate

Catalog ID

DDS-50-50-X-10

Compounds

50 240
628 plates

Amount

50 µL of 10 mM DMSO solutions

Plates and format

96-well plates, Greiner #65021, first and last columns empty, 80 compounds per plate

Please request for any other options through our contact form. We will be happy to deliver our library in any convenient for your project formats.

The hits from Discovery Diversity Sets are expected to be fast and easy to produce follow-up SAR libraries. All hits can be readily followed with analogues either from stock or from new syntheses through REAL database technology.

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Key features

  1. Novel compounds
  2. No singletons, 3-5 compounds per cluster
  3. 10 234 clusters in DDS-50
  4. No PAINS, only MedChem friendly compounds
  5. Express follow-up guaranteed

Distribution of clusters size (# of compounds with a cluster) in the library

Examples of molecules within a cluster

PPI-like scaffolds Cluster 4

GPCR-like structures Cluster 14

CNS-like scaffold Cluster 34

Kinase scaffold Cluster 11062

Molecular properties

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