Discovery Diversity Set
Top-quality diverse library of recently synthesized compounds
50 240 compounds
The success of high throughput screening in finding decent starting points for drug discovery heavily depends on the quality of the compound library. Compound screening libraries nowadays must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live chemistry” that can supply related chemical entities.
Enamine is constantly updating its Screening catalog with at least 150 000 newly synthesized compounds each year. These molecules are built on novel chemistry with use of the latest achievements in parallel chemistry and following industry trends in molecular properties and structural features. Every new library to be synthesized went through serial filters and is focused to bring novelty in a certain drug discovery area.
Discovery Diversity Sets (DDS) are aimed to bring latest chemistry to our customers within a smart clustering approach. Discovery Diversity Sets are based only on the lead-like compounds including representatives of all three main screening collections – HTS, Advanced, and Premium.
Typical Formats
Catalog No.
DDS-50-0-Z-2
Compounds
50 240
40 plates
Amount
≤ 300 nL of 2mM DMSO solutions
Plates and formats
1536-well microplates, Echo Qualified, Labcyte #LP-0400, 1280 compounds per plate, first four and last four columns empty
Catalog No.
DDS-50-10-Y-10
Compounds
50 240
157 plates
Amount
10 µL of 10 mM DMSO solutions
Plates and formats
384-well plates, Greiner #784201, 320 compounds per plate, 1,2 & 23,24 columns empty
Catalog No.
DDS-50-50-X-10
Compounds
50 240
628 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
96-well plates, Greiner #65021, first and last columns empty, 80 compounds per plate
Catalog No.
DDS-50
Compounds
50 240
Amount
Custom
Plates and formats
Any custom format
The hits from Discovery Diversity Sets are expected to be fast and easy to produce follow-up SAR libraries.
Download SD files
Key features
- Novel compounds
- No singletons, 3-5 compounds per cluster
- 10 234 clusters in DDS-50
- No PAINS, only MedChem friendly compounds
- Express follow-up guaranteed
Distribution of clusters size (# of compounds with a cluster) in the library

Examples of molecules within a cluster

PPI-like scaffolds Cluster 4

GPCR-like structures Cluster 14

CNS-like scaffold Cluster 34

Kinase scaffold Cluster 11062