Enamine Premium Collection contains 61 331 compounds having most favorable physicochemical properties (high Fsp³, low LogP and MW). They have been synthesized in our lead-oriented synthesis program. Remarkable success achieved by Enamine in synthesizing novel lead-like compound libraries is explained by usage of robust and sustainable chemical methodology which concept is based on development of the building block inventory. While designing new molecular scaffolds we not only address the issue of physicochemical properties and pharmacophore composition of the derived compounds but also the cost factor related to follow-up of the found hits. Owing to the high degree of chemistry validation and availability of the analogous building blocks from our catalog the hit-to-lead process runs fast and smoothly.

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