Developed to expand the structural diversity of Molecular Glues
800 compounds
Phenyl glutarimide (PG) derivatives represent a promising alternative chemotype of CRBN binders. Notably, the phenyl glutarimide scaffold offers several key advantages over more "conservative" CRBN ligands, such as IMiDs. These advantages include improved chemical stability, reduced molecular size and TPSA, enhanced ligand efficiency, and greater synthetic accessibility. For these reasons, we have identified various aryl glutarimides as an excellent starting point for the construction of a Molecular Glues Library.
Examples of the molecules in the library
Download SD file
Typical Formats
Catalog No.
PG-800-0-Z-20
Compounds
800
1 plate
Amount
≤ 300 nL of 20 mM of DMSO solutions
Plates and formats
1536-well Echo LDV microplates, first and last four columns empty, 1280 compounds per plate
Price
Catalog No.
PG-800-10-Y-20
Compounds
800
3 plates
Amount
10 µL of 20 mM DMSO solutions
Plates and formats
384-well Echo plates, Labcyte #LP-0200, 320 compounds per plate, first two and last two columns empty
Price
Catalog No.
PG-800-50-X-20
Compounds
800
10 plates
Amount
50 µL of 20 mM DMSO solutions
Plates and formats
96-well plates, 80 compounds per plate, first and last columns empty; Greiner #781270
Price
*We will be happy to provide our library in any other most convenient for your project format. Please select among the following our standard microplates: Greiner Bio-One 781270, 784201, 781280, 651201 or Echo Qualified 001-12782 (LP-0200), 001-14555 (PP-0200), 001-6969 (LP-0400), C52621 or send your preferred labware. Compounds pooling can be provided upon request.
Selected publication
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Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angewandte Chemie 2021, 60, 51, 6663-26670. DOI: 10.1002/anie.202108848
Support
We offer comprehensive support in developing your hit compounds. Naturally such programs are realised most efficiently when biological actives originate from our screening collection. However, even if the hit compounds are from the collections of other vendors lead identification and optimization projects can proceed most productively in our hands. Sometimes for this we only need to synthesize first examples of the given chemical series and validate synthesis route.
