Protein-Protein Interaction Library
Designed for discovery of novel PPI inhibitors
40 640 compounds
Having a pivotal role in multiple cellular processes, protein-protein interactions (PPIs) are responsible for the effects linked to the blockage of the substrate binding site. There are numerous examples of drug candidates that were withdrawn from clinical trials due to the unexpected effects of direct antagonists. This fact outlines the importance of developing new potent protein-protein interactions inhibitors.
We have carefully selected 40 640 diverse compounds specifically targeting PPIs. All compounds are stored as dry substances and they can be acquired in diverse custom formats. Using our PPI Library for hit discovery you receive multiple benefits allowing you to save on time and costs in lead generation:
- Dry stock of over 4M compounds for hit resupply and hit expansion.
- Low-cost synthesis of analogues within only 3 weeks through our REAL Database technology
- Medicinal chemistry support enhanced with on-site broad ADME/T panel
You have also an option to screen the Library directly at Enamine. In this case, we will be happy to offer discount on library cost depending on the collaboration scope.
Typical Formats
Catalog No.
PPI-40-Y-0
Compounds
40 640 127 plates
Amount
≤ 300 nL of 2 mM solutions in DMSO
Plates and formats
384-well micro plates, Greiner Cat. No. 784201; 1, 2 & 23, 24 columns empty, 320 compounds per plate
Price
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Catalog No.
PPI-40-Z-5
Compounds
40 640 32 plates
Amount
5 µL of 10 mM DMSO stock solutions
Plates and formats
1536-well microplates, Echo Qualified, first four and last four columns empty, 1280 compounds per plate
Price
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Catalog No.
PPI-40-Y-50
Compounds
40 640 127 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
384-well microplates, first two and last two columns empty, 320 compounds per plate
Price
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Catalog No.
PPI-40
Compounds
40 640
Amount
Custom
Plates and formats
Any custom format
Price
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Download SD files
Library code: PML-8960
Version: 18 November 2022
8 960 compounds
sublibrary of PPI-40
Library design
Systemic analysis of available structural data of numerous PPIs allowed us to develop dedicated approach to the library design. We have analyzed more than 20 different protein-protein complexes to highlight specific features of majority of potent inhibitors in this area. Several specific recognition patterns, like α-helix, β-sheet, PDZ-, PBD and bromodomains were used in the library design. As a result of Ligand- and Structure based in silico screening, we created the selection of compounds featuring:
- Specific recognition patterns, including hot spots analysis, key amino acids, secondary/tertiary structures, α-helices, ‘hot loops’ and specific protein domains affinity.
- Lead-like properties and sp3-rich core structural motifs. Compounds passed all including affiliated MedChem filters including PAINS.
- Latest chemistry and novel building blocks. Identified hits can be readily followed with synthesis of new analogs through REAL Database technology.
Examples of scaffolds populating PPI Library












Importantly, our team of experienced computational, synthetic, medicinal chemists and biologists is ready to address your specific needs in tackling protein-protein interaction of your interest. Please, challenge us with your biological concepts, computational ideas and synthetic designs.