Nucleoside Mimetics
Small library of specially synthesized compounds
320 compounds
Mimetics of nucleosides are special class of proven therapeutic agents, which already showed high efficacy in treatment of viral infections, cancer and bacterial disease. In spite of similar structural motifs and common moieties and even cores, many modified nucleosides display high selectivity to certain class of targets. This type of molecules is well-tunable when using at least two sites of possible modification. Recently, we developed few alternative parallel chemistry approaches to make these compounds more accessible within reasonable time and in cost-effective manner. Using our library for your hit finding you receive multiple benefits:
- Hit Confirmation support – resupply from dry samples, QC check, HPLC repurifiction, guaranteed resynthesis.
- Straightforward synthesis of follow-up libraries through our REAL Database technology.
- Medicinal chemistry support enhanced with on-site broad ADME panel.
Typical Formats
Catalog No.
NML-320-Y-0
Compounds
320 1 plate
Amount
≤ 300 nL of up 10 mM DMSO solutions
Plates and formats
384-well acoustic microplates, 320 compounds per plate, first two and last two columns empty
Price
This email address is being protected from spambots. You need JavaScript enabled to view it.
Catalog No.
NML-320-X-20
Compounds
320 4 plates
Amount
20 µL of 10 mM DMSO solutions
Plates and formats
96-well plates (Greiner Cat. No 651201), 80 compounds per plate, 1 & 12 columns empty
Price
This email address is being protected from spambots. You need JavaScript enabled to view it.
Catalog No.
NML-320-X-50
Compounds
320 4 plates
Amount
50 µL of 10 mM DMSO solutions
Plates and formats
96-well plates (Greiner Cat. No 650201), 80 compounds per plate, 1 & 12 columns empty
Price
This email address is being protected from spambots. You need JavaScript enabled to view it.
Catalog No.
NML-320
Compounds
320
Amount
Custom
Plates and formats
Any custom format
Price
This email address is being protected from spambots. You need JavaScript enabled to view it.
Download SD file
Library design
- Careful Substructure Search Search of nucleoside core fragments and their bioisosteric heterocycles with simultaneous presence of sugar-like moiety
- Strict MedChem Filters Removal of undesired functionalities, reactive groups and large aromatic fragments
- Chemotype Control Compounds with trivial structural fragments were mostly removed. Control of renovation of the library in accordance to new literature data.
Design of REAL Nucleoside mimetics dataset

REAL structures with validated synthetic procedures
- Combinatorial approach Over 100 000 Building Blocks immediately available for modification:
- Diazine heterocyclic cores mimic nucleobases
- alicyclic amino alcohols - sugars
- Filtering of unwanted functionalities & MedChem inspection
- Automated parallel synthesis Implementation of well-developed reaction procedures operated by highly experienced staff
Design of REAL Nucleoside mimetics dataset
