Epoxides for Drug Design
Epoxides are important heterocyclic units found in various naturally occurring molecules, some with potential bioactivities. At least fourteen drugs on the market are epoxide-containing. In addition, epoxides are valuable building blocks in medicinal chemistry. They react with nucleophiles in a ring-opening process to form new C-C, C-O and C-N bonds. Herein we have designed and synthesized a library of small heteroaliphatic epoxides for drug design.