Spirocyclic Piperidine Bioisostere

Piperidine ring is found in the structure of about one hundred drugs. In 2010, 2-azaspiro[3.3]heptane structure was proposed as a replacement to the piperidine ring leading to improved solubility and reducing metabolic degradation of bioactive compounds. In 2023, scientists from Enamine created a library of another promising piperidine analogue, 1‑azaspiro[3.3]heptane. This scaffold had similar basicity of the nitrogen atom, similar solubility, similar lipophilicity; and improved metabolic stability over the common 2-azaspiro[3.3]heptane. Try our azaspiro[3.3]heptanes in your research!

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