α-Fluoroketones for Drug Discovery

α-Fluoroketones, particularly α-fluoromethyl ketones (FMK), act as a robust and selective chemical handle for irreversible binding of bioactive molecules to cysteine residues in target proteins. FMK molecules are present in various compound classes, including several commercial peptidic caspase inhibitors related to Z-VAD-FMK, halosteroid tralonide, and more. Additionally, α-fluoroketones are frequently utilized in drug discovery projects as advanced ketone building blocks suitable for Claisen-Schmidt condensation and reductive amination, that produce fluorinated bioactive molecules with enhanced properties. Try our α-fluoroketones in our next project!