Thietane Dioxide

Thietane dioxide, the smallest cyclic sulfone, shares notable similarities with cyclobutane. Compared to other four-membered ring structures, thietane dioxide reduces lipophilicity while only slightly increasing molecular volume. A recent study demonstrated that replacing a peptide bond with thietane dioxide led to significant improvements in both substance metabolic stability and target selectivity. Enamine offers a diverse range of thietane dioxides, including promising spirocycles, amino acids, and positional isomers.