Spirocyclic Azetidines for Medicinal Chemistry

What if we could freely steer the geometry of lead compounds? With the ability to vary the ring fusion site, size of the rings, and the substitution patterns, this task is well addressed by spirocyclic azetidine structures. Furthermore, unlike analogous pyrrolidines or aromatic rings, spirocyclic azetidines are poorly recognized by degradation enzymes. Thus, introduction of spirocyclic azetidines has become an effective method for mitigating early drug clearance.

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