Spirocyclic Azetidines for Medicinal Chemistry
What if we could freely steer the geometry of lead compounds? With the ability to vary the ring fusion site, size of the rings, and the substitution patterns, this task is well addressed by spirocyclic azetidine structures. Furthermore, unlike analogous pyrrolidines or aromatic rings, spirocyclic azetidines are poorly recognized by degradation enzymes. Thus, introduction of spirocyclic azetidines has become an effective method for mitigating early drug clearance.
Case studies
We offer
More than 100 of spirocyclic azetidines from stock on a 5-10 g scale.
EN300-7322115
