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Acetylenes are used in the Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction – “click chemistry”. 1,2,3-Triazole function formed by click reaction between an azide and alkyne bears a physicochemical resemblance to the amide bond. Using “click chemistry” one can efficiently connect complex molecules such as ligands and tool compounds.

In this context, Enamine offers a library of unique functionalized alkynes that can be used as linker compounds, for example, in synthesis of PROTACs.

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We offer:

>100 unique acetylenes on a 5-50 g scale from stock.

 

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