Fluorosulfates and Sulfamoyl Fluorides for Drug Design
Aryl fluorosulfates and sulfamoyl fluorides are widely used in chemical biology, medicinal chemistry and agrochemistry. The former exhibit chemoselective reactivity with the side chains of tyrosine, lysine, serine and histidine in the proteins, and can be used to target non-enzymes as well as enzymes. Depending on the nature of the substituent, the -OSO2F unit can be a good leaving group or a robust connector. The fluorosulfates are quite stable toward hydrolysis under neutral or acidic conditions. The N-disubstituted sulfamoyl fluorides are stable toward hydrolysis under basic condition, inert toward a wide range of nucleophiles and dramatically more robust than analogous chlorides. In this context, Enamine offers a library of unique aryl fluorosulfates and sulfamoyl fluorides for drug design.
Properties of ROSO2F and R2NSO2F
Dual reactivity of fluorosulfates
Reactivity and stability of the sulfamoyl fluorides
We offer:
>100 unique fluorosulfates and sulfamoyl fluorides in gram amounts in stock.
MedChem Highlights
- Saturated Bioisosteres for ortho-substituted Benzenes
- Aliphatic Trifluoroborates (-BF3) for C-C couplings
- Functionalized Vinyl Boronates for C-C couplings
- Unique 3D-shaped Spirocycles
- Water-soluble non-classical benzene mimics
- gem-Difluorinated Amines for Drug Design
- Fluorosulfates and Sulfamoyl Fluorides
- Alkyne-containing Linkers
- Structurally optimized tetrazines for rapid biological labeling
- Building blocks and linkers for PROTAC synthesis
- Heterocyclic Sulfonyl Fluorides
- Silicon-Containing Building Blocks
- Epoxides for Drug Design
- Analogues of CF3-Pyridine for Drug Design
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Diazirines
- Oxetane-containing Building Blocks
- SF5-Building Blocks
- Stannanes for coupling reactions
- Sulfoximines for Drug Design
- Heterocyclic scaffolds
- Azide-linkers for Drug Design
- Unnatural Amino Acids
- Cubanes for Medicinal Chemistry
- Benzoxaboroles for Drug Design