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Hydrazine fragments can be frequently found in the structures of bioactive compounds and some types of natural products. Saturated heterocycles containing the hydrazine feature act as aza-analogues of piperidines, pyrrolidines, and azepines, and help elevate molecular polarity, create chemically accessible functionalization sites, and fine-tune structural and electronic properties. Numerous bioactive molecules are based on the structure of piperazic acid, for example, the KRAS G12D inhibitor RMC-9805 that recently entered Phase 1 clinical trials. Enamine offers a collection of cyclic and bicyclic saturated hydrazine structures.

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Over 50 cyclic hydrazines and hydrazides from stock on 5-10 gram scale.

 

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