Warheads are reactive moieties that enable covalent binding to target enzymes. α-Aminonitriles are particularly effective for targeting cysteine residues, as they minimize off-target interactions with intracellular glutathione. Recently, aminonitrile-based inhibitors have been developed for dipeptidyl peptidase 1 (brensocatib) and the SARS-CoV-2 main protease (nirmatrelvir, simnotrelvir, ibuzatrelvir). Explore our aminonitriles for your cysteine-targeting applications!
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Over 100 α-aminonitriles from stock on 5-10 gram scale.
