Fluoroalkyl ethers for Drug Design

More than 20% of all modern pharmaceuticals and up to 30% of agrochemicals contain at least one fluorine atom. As a typical fluoroalkoxy group, trifluoromethoxy (-OCF₃) is prevalent in bioactive compounds. Compared to the well-studied -OCF₃ group, its bulkier analogue, pentafluoroethoxy (-OC₂F₅) group, has been much less explored. In fact, -OC₂F₅ and -OCF₃ groups have similar electronic properties, lipophilicity and metabolic stability. In this context, Enamine offers a library of various fluoroalkyl-substituted ethers for drug design.