Bridged Pyrrolidine with Reduced Lipophilicity

Adding a bridge on a saturated heterocycle not only results in entropy reduction but also enhances the solubility in water and decreases lipophilicity (logD). Five years ago, Enamine scientists published a robust synthesis of the functionalized bridged pyrrolidines and showed that the usage of these advanced building blocks instead of pyrrolidines successfully addressed the fundamental medchem challenges. We now have 253 building blocks based on the 2,4‑methanopyrrolidine core in our stock. Try our rich library of bridged pyrrolidines for constructing your molecules!

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More than 100 2-azabicyclo[2.1.1]hexanes from stock on 5-10 gram scale.


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