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Bioisosteric replacement is a common method of improving properties of drug molecules without compromising their overall binding to the biological target. Saturated bioisosteres of ortho-substituted benzene were introduced in 2020, and they have been making their way into pharmaceuticals over the past years. Bioisosteres improve metabolic stability, solubility, and lipophilicity of molecules.

Saturated Bioisosteres of ortho-substituted Phenyl Ring

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More than 100 ortho-benzene bioisosteres from stock on a multigram scale.

 

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