Analogues of CF3-Pyridine for Drug Design
More than 100 FDA-approved drugs contain pyridine ring and another 100 have been in clinical trials. Examples containing CF3-pyridine moiety include the antiviral drug Tipranavir and drug candidates Taranabant, Velneperit,
SB-705498. Besides, CF3-pyridine containing compounds have been playing a fundamental role in agrochemistry. The introduction of fluorine-containing group alters important pharmacokinetic properties of molecular scaffolds. Herein we have designed and synthesized a library of CF3-substituted pyridine analogues for drug design and agrochemistry.
Design
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>100 unique CF3-pyridine analogues on a 5-50 g scale from stock
MedChem Highlights
- Heterocyclic Sulfonyl Fluorides
- Silicon-Containing Building Blocks
- Epoxides for Drug Design
- Analogues of CF3-Pyridine for Drug Design
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks for Drug Design
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Diazirines
- Oxetane-containing Building Blocks
- SF5-Building Blocks
- Stannanes for coupling reactions
- Sulfoximines for Drug Design
- Saturated Bioisosteres of Benzene
- Heterocyclic scaffolds
- Macrocycles
- Azide-linkers for Drug Design
- Unnatural Amino Acids
- Cubane-containing building blocks
- Benzoxaboroles for Drug Design