Oxetane-incorporating Building Blocks

Increasing numbers of drug candidate molecules contain oxetane moieties, which are compact fragments with beneficial effects on the sp³ content and lipophilicity of molecules. Reagents for incorporating oxetanes into complex organic molecules are in high demand. Methyleneoxetanes are simple and versatile compounds that enable the construction of non-chiral oxetanes through standard as well as innovative organic reactions. Enamine scientists have prepared some of those reagents and even developed novel transformations with them.