Methyl Sulfoximines for Medicinal Chemistry

The molecular fragment of sulfoximines is considered the rising star of modern medicinal chemistry. Sulfone, sulfonamide, amine, and alcohol moieties have been replaced by sulfoximine often producing substances with improved water solubility, reduced lipophilicity, better permeability, lower efflux and other desirable features. Owning to their small size, S-methyl sulfoximines represent the most common type of these substances applied in designing biologically active chemical structures.

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Case studies

Replacement of sulfonamide with methyl sulfoximine:

  • increases aqueous solubility,
  • improves cellular permeability,
  • reduces efflux.

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More than 100 of methyl sulfoximines from stock on a 5-10 g scale.


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