Conformational rigidification of flexible compounds by introducing a ring is a popular strategy in drug design. The resulting cyclic analogues usually have a reduced conformational entropy penalty upon binding to a protein target. A conformational restriction can also be imposed by introduction of a spirocyclic ring. Spirocyclic systems are 3D-shaped, in strict contrast to flatten benzene compounds. It is especially true for polycyclic compounds. In this context, Enamine offers a library of innovative three-cyclic scaffolds for drug design.
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