CF3-Diazirines for photoaffinity labeling
Diazirines are the smallest molecules used in photochemical cross-linking and photoaffinity labeling approaches. Light radiation transfers them into highly reactive carbenes that attach to the molecular fragment in their immediate vicinity. However, unwanted reactions may occur and scramble the labeling process, unless… a CF3-group comes to help! Our set of CF3‑diazirines has been developed to make derived probe molecules act at the time and place you shine light on them, not elsewhere.
Key advantage
A common problem with diazirine photo-labeling is formation of diazo species that release carbenes with a time lag allowing diffusion away from the intended binding site and off-target binding. In 1980, Brunner et al. invented CF3‑diazirines to mitigate this mechanism. The off-target mechanism is reduced due to the notoriously low reactivity of CF3‑diazo compounds.
We offer
More than 30 of CF3-diazirines from stock on a 5-10 g scale.
MedChem Highlights
- CF3-Diazirines for photoaffinity labeling
- Boron-containing heterocyclic scaffolds with active halogens
- Aliphatic Pinacol Boronates for Medicinal Chemistry
- Deuterium-Containing Building Blocks for Drug Design
- Analogues of Piperidine for Drug Design
- SnAP Reagents
- Fluoroalkyl ethers for Drug Design
- N-Nitrosamines
- N-Trifluoromethyl Azoles for Drug Discovery
- Cyclic sulfates and sulfamidates as alkylating reagents
- Saturated Bioisosteres for ortho-substituted Benzenes
- Aliphatic Trifluoroborates (-BF3) for C-C couplings
- Functionalized Vinyl Boronates for C-C couplings
- Unique 3D-shaped Spirocycles
- Water-soluble non-classical benzene mimics
- gem-Difluorinated Amines for Drug Design
- Fluorosulfates and Sulfamoyl Fluorides
- Alkyne-containing Linkers
- Structurally optimized tetrazines for rapid biological labeling
- Building blocks and linkers for PROTAC synthesis
- Heterocyclic Sulfonyl Fluorides
- Silicon-Containing Building Blocks
- Epoxides for Drug Design
- Analogues of CF3-Pyridine for Drug Design
- Piperazine Bioisosteres for Drug Design
- Sugar-like Building Blocks for Drug Design
- Cyclic Sulfonamides for Drug Design
- Morpholine Bioisosteres for Drug Design
- P(O)Me2-containing Building Blocks
- Saturated Bioisosteres of ortho-/meta-substituted Benzenes
- Saturated bioisosteres of para-substituted benzenes
- Sulfonyl fluorides (-SO2F)
- Diazirines
- Oxetane-containing Building Blocks
- SF5-Building Blocks
- Stannanes for coupling reactions
- Sulfoximines for Drug Design
- Heterocyclic scaffolds
- Azide-linkers for Drug Design
- Unnatural Amino Acids
- Cubanes for Medicinal Chemistry
- Benzoxaboroles for Drug Design